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Low-intensity pulsed ultrasound decreases major amputation in patients with critical limb ischemia: 5-year follow-up study
Various therapeutic strategies for angiogenesis are performed to improve symptoms in patients with critical limb ischemia (CLI). Pre-clinical studies have shown that low-intensity pulsed ultrasound (LIPUS) exposure induces angiogenesis. LIPUS may be a new stratergy for treatment of CLI. The purpose...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376014/ https://www.ncbi.nlm.nih.gov/pubmed/34411183 http://dx.doi.org/10.1371/journal.pone.0256504 |
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author | Mohamad Yusoff, Farina Kajikawa, Masato Yamaji, Takayuki Takaeko, Yuji Hashimoto, Yu Mizobuchi, Aya Han, Yiming Kishimoto, Shinji Maruhashi, Tatsuya Nakashima, Ayumu Higashi, Yukihito |
author_facet | Mohamad Yusoff, Farina Kajikawa, Masato Yamaji, Takayuki Takaeko, Yuji Hashimoto, Yu Mizobuchi, Aya Han, Yiming Kishimoto, Shinji Maruhashi, Tatsuya Nakashima, Ayumu Higashi, Yukihito |
author_sort | Mohamad Yusoff, Farina |
collection | PubMed |
description | Various therapeutic strategies for angiogenesis are performed to improve symptoms in patients with critical limb ischemia (CLI). Pre-clinical studies have shown that low-intensity pulsed ultrasound (LIPUS) exposure induces angiogenesis. LIPUS may be a new stratergy for treatment of CLI. The purpose of this pilot trial was to evaluate outcomes in patients with CLI who were treated with LIPUS. Fourteen patients with CLI, who were not candidates for angioplasty or surgical revascularization, were enrolled in this study. Historical control data were obtained from the Hiroshima University PAD database. The primary endpoints were major amputation and death. The outcomes were compared in 16 lower limbs of the 14 patients with CLI who were treated with LIPUS and in 14 lower limbs of 14 patients with CLI as historical controls. All patients were followed for after 5 years after treatment with LIPUS. The mean duration of LIPUS exposure in the LIPUS group was 381± 283 days. During the 5-year follow-up periods, there were 3 major amputations and 7 deaths in the LIPUS group and there were 14 major amputations and 7 deaths in the historical control group. The overall amputation-free survival rate was significantly higher in patients who were treated with LIPUS than in historical controls. There was no significant difference between overall mortality-free survival rates in the LIPUS group and historical control group. LIPUS is a noninvasive option for therapeutic angiogenesis with the potential to reduce the incidence of major amputations in patients with CLI. |
format | Online Article Text |
id | pubmed-8376014 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-83760142021-08-20 Low-intensity pulsed ultrasound decreases major amputation in patients with critical limb ischemia: 5-year follow-up study Mohamad Yusoff, Farina Kajikawa, Masato Yamaji, Takayuki Takaeko, Yuji Hashimoto, Yu Mizobuchi, Aya Han, Yiming Kishimoto, Shinji Maruhashi, Tatsuya Nakashima, Ayumu Higashi, Yukihito PLoS One Research Article Various therapeutic strategies for angiogenesis are performed to improve symptoms in patients with critical limb ischemia (CLI). Pre-clinical studies have shown that low-intensity pulsed ultrasound (LIPUS) exposure induces angiogenesis. LIPUS may be a new stratergy for treatment of CLI. The purpose of this pilot trial was to evaluate outcomes in patients with CLI who were treated with LIPUS. Fourteen patients with CLI, who were not candidates for angioplasty or surgical revascularization, were enrolled in this study. Historical control data were obtained from the Hiroshima University PAD database. The primary endpoints were major amputation and death. The outcomes were compared in 16 lower limbs of the 14 patients with CLI who were treated with LIPUS and in 14 lower limbs of 14 patients with CLI as historical controls. All patients were followed for after 5 years after treatment with LIPUS. The mean duration of LIPUS exposure in the LIPUS group was 381± 283 days. During the 5-year follow-up periods, there were 3 major amputations and 7 deaths in the LIPUS group and there were 14 major amputations and 7 deaths in the historical control group. The overall amputation-free survival rate was significantly higher in patients who were treated with LIPUS than in historical controls. There was no significant difference between overall mortality-free survival rates in the LIPUS group and historical control group. LIPUS is a noninvasive option for therapeutic angiogenesis with the potential to reduce the incidence of major amputations in patients with CLI. Public Library of Science 2021-08-19 /pmc/articles/PMC8376014/ /pubmed/34411183 http://dx.doi.org/10.1371/journal.pone.0256504 Text en © 2021 Mohamad Yusoff et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Mohamad Yusoff, Farina Kajikawa, Masato Yamaji, Takayuki Takaeko, Yuji Hashimoto, Yu Mizobuchi, Aya Han, Yiming Kishimoto, Shinji Maruhashi, Tatsuya Nakashima, Ayumu Higashi, Yukihito Low-intensity pulsed ultrasound decreases major amputation in patients with critical limb ischemia: 5-year follow-up study |
title | Low-intensity pulsed ultrasound decreases major amputation in patients with critical limb ischemia: 5-year follow-up study |
title_full | Low-intensity pulsed ultrasound decreases major amputation in patients with critical limb ischemia: 5-year follow-up study |
title_fullStr | Low-intensity pulsed ultrasound decreases major amputation in patients with critical limb ischemia: 5-year follow-up study |
title_full_unstemmed | Low-intensity pulsed ultrasound decreases major amputation in patients with critical limb ischemia: 5-year follow-up study |
title_short | Low-intensity pulsed ultrasound decreases major amputation in patients with critical limb ischemia: 5-year follow-up study |
title_sort | low-intensity pulsed ultrasound decreases major amputation in patients with critical limb ischemia: 5-year follow-up study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376014/ https://www.ncbi.nlm.nih.gov/pubmed/34411183 http://dx.doi.org/10.1371/journal.pone.0256504 |
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