The calcium-binding protein S100B reduces IL6 production in malignant melanoma via inhibition of RSK cellular signaling

S100B is frequently elevated in malignant melanoma. A regulatory mechanism was uncovered here in which elevated S100B lowers mRNA and secreted protein levels of interleukin-6 (IL6) and inhibits an autocrine loop whereby IL6 activates STAT3 signaling. Our results showed that S100B affects IL6 express...

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Detalles Bibliográficos
Autores principales: Alasady, Milad J., Terry, Alexander R., Pierce, Adam D., Cavalier, Michael C., Blaha, Catherine S., Adipietro, Kaylin A., Wilder, Paul T., Weber, David J., Hay, Nissim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376063/
https://www.ncbi.nlm.nih.gov/pubmed/34411141
http://dx.doi.org/10.1371/journal.pone.0256238

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376063/
https://www.ncbi.nlm.nih.gov/pubmed/34411141
http://dx.doi.org/10.1371/journal.pone.0256238

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