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A population pharmacokinetic‐pharmacodynamic model of YH12852, a highly selective 5‐hydroxytryptamine 4 receptor agonist, in healthy subjects and patients with functional constipation

YH12852, a novel, highly selective 5‐hydroxytryptamine 4 (5‐HT(4)) receptor agonist, is currently under development to treat patients with functional constipation. In this study, we aimed to develop a pharmacokinetic (PK)–pharmacodynamic (PD) model that adequately described the time courses of the p...

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Detalles Bibliográficos
Autores principales:	Kim, Siun, Lee, Hyun A., Jang, Seong Bok, Lee, Howard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376136/ https://www.ncbi.nlm.nih.gov/pubmed/34085769 http://dx.doi.org/10.1002/psp4.12664

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