PK/PD modeling of FXI antisense oligonucleotides to bridge the dose‐FXI activity relation from healthy volunteers to end‐stage renal disease patients

IONIS‐FXI(RX) (BAY2306001) is an antisense oligonucleotide that inhibits the synthesis of coagulation factor XI (FXI) and has been investigated in healthy volunteers and patients with end‐stage renal disease (ESRD). FXI‐LICA (BAY2976217) shares the same RNA sequence as IONIS‐FXI(RX) but contains a G...

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Detalles Bibliográficos
Autores principales: Willmann, Stefan, Marostica, Eleonora, Snelder, Nelleke, Solms, Alexander, Jensen, Markus, Lobmeyer, Maximilian, Lensing, Anthonie W. A., Bethune, Claudette, Morgan, Erin, Yu, Rosie Z., Wang, Yanfeng, Jung, Shiangtung W., Geary, Richard, Bhanot, Sanjay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376138/
https://www.ncbi.nlm.nih.gov/pubmed/34085768
http://dx.doi.org/10.1002/psp4.12663

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