Whole-genome analysis of SARS-CoV-2 samples indicate no tissue specific genetic adaptation of the virus in COVID-19 patients’ upper and lower respiratory tract

Sample panels of SARS-CoV-2 cases were retrospectively whole-genome sequenced. In three individuals, samples of upper and lower respiratory tract resulted in identical sequences suggesting virus stability including the spike protein cleavage site. In a fourth case, low-level intra-host genomic evolu...

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Autores principales: Wylezich, Claudia, Schaller, Tina, Claus, Rainer, Hirschbühl, Klaus, Märkl, Bruno, Kling, Elisabeth, Spring, Oliver, Höper, Dirk, Schlegel, Jürgen, Beer, Martin, Dintner, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376524/
https://www.ncbi.nlm.nih.gov/pubmed/34536911
http://dx.doi.org/10.1016/j.diagmicrobio.2021.115520
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author Wylezich, Claudia
Schaller, Tina
Claus, Rainer
Hirschbühl, Klaus
Märkl, Bruno
Kling, Elisabeth
Spring, Oliver
Höper, Dirk
Schlegel, Jürgen
Beer, Martin
Dintner, Sebastian
author_facet Wylezich, Claudia
Schaller, Tina
Claus, Rainer
Hirschbühl, Klaus
Märkl, Bruno
Kling, Elisabeth
Spring, Oliver
Höper, Dirk
Schlegel, Jürgen
Beer, Martin
Dintner, Sebastian
author_sort Wylezich, Claudia
collection PubMed
description Sample panels of SARS-CoV-2 cases were retrospectively whole-genome sequenced. In three individuals, samples of upper and lower respiratory tract resulted in identical sequences suggesting virus stability including the spike protein cleavage site. In a fourth case, low-level intra-host genomic evolution and a unique 5-nucleotide deletion was observed.
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spelling pubmed-83765242021-08-20 Whole-genome analysis of SARS-CoV-2 samples indicate no tissue specific genetic adaptation of the virus in COVID-19 patients’ upper and lower respiratory tract Wylezich, Claudia Schaller, Tina Claus, Rainer Hirschbühl, Klaus Märkl, Bruno Kling, Elisabeth Spring, Oliver Höper, Dirk Schlegel, Jürgen Beer, Martin Dintner, Sebastian Diagn Microbiol Infect Dis Article Sample panels of SARS-CoV-2 cases were retrospectively whole-genome sequenced. In three individuals, samples of upper and lower respiratory tract resulted in identical sequences suggesting virus stability including the spike protein cleavage site. In a fourth case, low-level intra-host genomic evolution and a unique 5-nucleotide deletion was observed. The Authors. Published by Elsevier Inc. 2021-12 2021-08-20 /pmc/articles/PMC8376524/ /pubmed/34536911 http://dx.doi.org/10.1016/j.diagmicrobio.2021.115520 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Wylezich, Claudia
Schaller, Tina
Claus, Rainer
Hirschbühl, Klaus
Märkl, Bruno
Kling, Elisabeth
Spring, Oliver
Höper, Dirk
Schlegel, Jürgen
Beer, Martin
Dintner, Sebastian
Whole-genome analysis of SARS-CoV-2 samples indicate no tissue specific genetic adaptation of the virus in COVID-19 patients’ upper and lower respiratory tract
title Whole-genome analysis of SARS-CoV-2 samples indicate no tissue specific genetic adaptation of the virus in COVID-19 patients’ upper and lower respiratory tract
title_full Whole-genome analysis of SARS-CoV-2 samples indicate no tissue specific genetic adaptation of the virus in COVID-19 patients’ upper and lower respiratory tract
title_fullStr Whole-genome analysis of SARS-CoV-2 samples indicate no tissue specific genetic adaptation of the virus in COVID-19 patients’ upper and lower respiratory tract
title_full_unstemmed Whole-genome analysis of SARS-CoV-2 samples indicate no tissue specific genetic adaptation of the virus in COVID-19 patients’ upper and lower respiratory tract
title_short Whole-genome analysis of SARS-CoV-2 samples indicate no tissue specific genetic adaptation of the virus in COVID-19 patients’ upper and lower respiratory tract
title_sort whole-genome analysis of sars-cov-2 samples indicate no tissue specific genetic adaptation of the virus in covid-19 patients’ upper and lower respiratory tract
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376524/
https://www.ncbi.nlm.nih.gov/pubmed/34536911
http://dx.doi.org/10.1016/j.diagmicrobio.2021.115520
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