Identification of hippocampal cortical microinfarcts on postmortem 3-T magnetic resonance imaging

Cortical microinfarcts (CMI) are increasingly recognized in the neurological community as a biomarker related to cognitive impairment and dementia. If their radiological depiction has been largely described in experimental settings using ultra-high-field magnetic resonance imaging (MRI), less is kno...

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Autores principales: Scheffler, Max, Salomir, Rares, Maturana, Enrique, Montandon, Marie-Louise, Kövari, Enikö V., Haller, Sven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376696/
https://www.ncbi.nlm.nih.gov/pubmed/33909116
http://dx.doi.org/10.1007/s00234-021-02717-8
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author Scheffler, Max
Salomir, Rares
Maturana, Enrique
Montandon, Marie-Louise
Kövari, Enikö V.
Haller, Sven
author_facet Scheffler, Max
Salomir, Rares
Maturana, Enrique
Montandon, Marie-Louise
Kövari, Enikö V.
Haller, Sven
author_sort Scheffler, Max
collection PubMed
description Cortical microinfarcts (CMI) are increasingly recognized in the neurological community as a biomarker related to cognitive impairment and dementia. If their radiological depiction has been largely described in experimental settings using ultra-high-field magnetic resonance imaging (MRI), less is known about their visibility on routinely used 3-T MRI. In this radiologic-pathologic correlation study, using 3-T post-mortem MRI, we searched for hippocampal CMI, in a double-blinded fashion, and found that only 4/36, or 11%, were clearly demonstrated on both radiological and histopathological exams.
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spelling pubmed-83766962021-09-02 Identification of hippocampal cortical microinfarcts on postmortem 3-T magnetic resonance imaging Scheffler, Max Salomir, Rares Maturana, Enrique Montandon, Marie-Louise Kövari, Enikö V. Haller, Sven Neuroradiology Short Report Cortical microinfarcts (CMI) are increasingly recognized in the neurological community as a biomarker related to cognitive impairment and dementia. If their radiological depiction has been largely described in experimental settings using ultra-high-field magnetic resonance imaging (MRI), less is known about their visibility on routinely used 3-T MRI. In this radiologic-pathologic correlation study, using 3-T post-mortem MRI, we searched for hippocampal CMI, in a double-blinded fashion, and found that only 4/36, or 11%, were clearly demonstrated on both radiological and histopathological exams. Springer Berlin Heidelberg 2021-04-28 2021 /pmc/articles/PMC8376696/ /pubmed/33909116 http://dx.doi.org/10.1007/s00234-021-02717-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Short Report
Scheffler, Max
Salomir, Rares
Maturana, Enrique
Montandon, Marie-Louise
Kövari, Enikö V.
Haller, Sven
Identification of hippocampal cortical microinfarcts on postmortem 3-T magnetic resonance imaging
title Identification of hippocampal cortical microinfarcts on postmortem 3-T magnetic resonance imaging
title_full Identification of hippocampal cortical microinfarcts on postmortem 3-T magnetic resonance imaging
title_fullStr Identification of hippocampal cortical microinfarcts on postmortem 3-T magnetic resonance imaging
title_full_unstemmed Identification of hippocampal cortical microinfarcts on postmortem 3-T magnetic resonance imaging
title_short Identification of hippocampal cortical microinfarcts on postmortem 3-T magnetic resonance imaging
title_sort identification of hippocampal cortical microinfarcts on postmortem 3-t magnetic resonance imaging
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376696/
https://www.ncbi.nlm.nih.gov/pubmed/33909116
http://dx.doi.org/10.1007/s00234-021-02717-8
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