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Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo

In Parkinson's disease, dopamine‐containing nigrostriatal neurons undergo profound degeneration. Tyrosine hydroxylase (TH) is the rate‐limiting enzyme in dopamine biosynthesis. TH increases in vitro formation of reactive oxygen species, and previous animal studies have reported links between cy...

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Detalles Bibliográficos
Autores principales:	Vecchio, Laura M., Sullivan, Patricia, Dunn, Amy R., Bermejo, Marie Kristel, Fu, Rong, Masoud, Shababa T., Gregersen, Emil, Urs, Nikhil M., Nazari, Reza, Jensen, Poul Henning, Ramsey, Amy, Goldstein, David S., Miller, Gary W., Salahpour, Ali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	ORIGINAL ARTICLES
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376767/ https://www.ncbi.nlm.nih.gov/pubmed/33991113 http://dx.doi.org/10.1111/jnc.15432

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