Consistent tumorigenesis with self-assembled hydrogels enables high-powered murine cancer studies

Preclinical cancer research is heavily dependent on allograft and xenograft models, but current approaches to tumor inoculation yield inconsistent tumor formation and growth, ultimately wasting valuable resources (e.g., animals, time, and money) and limiting experimental progress. Here we demonstrat...

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Detalles Bibliográficos
Autores principales: Grosskopf, Abigail K., Correa, Santiago, Baillet, Julie, Maikawa, Caitlin L., Gale, Emily C., Brown, Ryanne A., Appel, Eric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376877/
https://www.ncbi.nlm.nih.gov/pubmed/34413455
http://dx.doi.org/10.1038/s42003-021-02500-8
Descripción
Sumario:Preclinical cancer research is heavily dependent on allograft and xenograft models, but current approaches to tumor inoculation yield inconsistent tumor formation and growth, ultimately wasting valuable resources (e.g., animals, time, and money) and limiting experimental progress. Here we demonstrate a method for tumor inoculation using self-assembled hydrogels to reliably generate tumors with low variance in growth. The observed reduction in model variance enables smaller animal cohorts, improved effect observation and higher powered studies.

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