Consistent tumorigenesis with self-assembled hydrogels enables high-powered murine cancer studies

Preclinical cancer research is heavily dependent on allograft and xenograft models, but current approaches to tumor inoculation yield inconsistent tumor formation and growth, ultimately wasting valuable resources (e.g., animals, time, and money) and limiting experimental progress. Here we demonstrat...

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Autores principales: Grosskopf, Abigail K., Correa, Santiago, Baillet, Julie, Maikawa, Caitlin L., Gale, Emily C., Brown, Ryanne A., Appel, Eric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376877/
https://www.ncbi.nlm.nih.gov/pubmed/34413455
http://dx.doi.org/10.1038/s42003-021-02500-8
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author Grosskopf, Abigail K.
Correa, Santiago
Baillet, Julie
Maikawa, Caitlin L.
Gale, Emily C.
Brown, Ryanne A.
Appel, Eric A.
author_facet Grosskopf, Abigail K.
Correa, Santiago
Baillet, Julie
Maikawa, Caitlin L.
Gale, Emily C.
Brown, Ryanne A.
Appel, Eric A.
author_sort Grosskopf, Abigail K.
collection PubMed
description Preclinical cancer research is heavily dependent on allograft and xenograft models, but current approaches to tumor inoculation yield inconsistent tumor formation and growth, ultimately wasting valuable resources (e.g., animals, time, and money) and limiting experimental progress. Here we demonstrate a method for tumor inoculation using self-assembled hydrogels to reliably generate tumors with low variance in growth. The observed reduction in model variance enables smaller animal cohorts, improved effect observation and higher powered studies.
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spelling pubmed-83768772021-09-02 Consistent tumorigenesis with self-assembled hydrogels enables high-powered murine cancer studies Grosskopf, Abigail K. Correa, Santiago Baillet, Julie Maikawa, Caitlin L. Gale, Emily C. Brown, Ryanne A. Appel, Eric A. Commun Biol Article Preclinical cancer research is heavily dependent on allograft and xenograft models, but current approaches to tumor inoculation yield inconsistent tumor formation and growth, ultimately wasting valuable resources (e.g., animals, time, and money) and limiting experimental progress. Here we demonstrate a method for tumor inoculation using self-assembled hydrogels to reliably generate tumors with low variance in growth. The observed reduction in model variance enables smaller animal cohorts, improved effect observation and higher powered studies. Nature Publishing Group UK 2021-08-19 /pmc/articles/PMC8376877/ /pubmed/34413455 http://dx.doi.org/10.1038/s42003-021-02500-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Grosskopf, Abigail K.
Correa, Santiago
Baillet, Julie
Maikawa, Caitlin L.
Gale, Emily C.
Brown, Ryanne A.
Appel, Eric A.
Consistent tumorigenesis with self-assembled hydrogels enables high-powered murine cancer studies
title Consistent tumorigenesis with self-assembled hydrogels enables high-powered murine cancer studies
title_full Consistent tumorigenesis with self-assembled hydrogels enables high-powered murine cancer studies
title_fullStr Consistent tumorigenesis with self-assembled hydrogels enables high-powered murine cancer studies
title_full_unstemmed Consistent tumorigenesis with self-assembled hydrogels enables high-powered murine cancer studies
title_short Consistent tumorigenesis with self-assembled hydrogels enables high-powered murine cancer studies
title_sort consistent tumorigenesis with self-assembled hydrogels enables high-powered murine cancer studies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376877/
https://www.ncbi.nlm.nih.gov/pubmed/34413455
http://dx.doi.org/10.1038/s42003-021-02500-8
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