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The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology
Preclinical testing is a crucial step in evaluating cancer therapeutics. We aimed to establish a significant resource of patient-derived xenografts (PDXs) of prostate cancer for rapid and systematic evaluation of candidate therapies. The PDX collection comprises 59 tumors collected from 30 patients...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376965/ https://www.ncbi.nlm.nih.gov/pubmed/34413304 http://dx.doi.org/10.1038/s41467-021-25175-5 |
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| author | Risbridger, Gail P. Clark, Ashlee K. Porter, Laura H. Toivanen, Roxanne Bakshi, Andrew Lister, Natalie L. Pook, David Pezaro, Carmel J. Sandhu, Shahneen Keerthikumar, Shivakumar Quezada Urban, Rosalia Papargiris, Melissa Kraska, Jenna Madsen, Heather B. Wang, Hong Richards, Michelle G. Niranjan, Birunthi O’Dea, Samantha Teng, Linda Wheelahan, William Li, Zhuoer Choo, Nicholas Ouyang, John F. Thorne, Heather Devereux, Lisa Hicks, Rodney J. Sengupta, Shomik Harewood, Laurence Iddawala, Mahesh Azad, Arun A. Goad, Jeremy Grummet, Jeremy Kourambas, John Kwan, Edmond M. Moon, Daniel Murphy, Declan G. Pedersen, John Clouston, David Norden, Sam Ryan, Andrew Furic, Luc Goode, David L. Frydenberg, Mark Lawrence, Mitchell G. Taylor, Renea A. |
| author_facet | Risbridger, Gail P. Clark, Ashlee K. Porter, Laura H. Toivanen, Roxanne Bakshi, Andrew Lister, Natalie L. Pook, David Pezaro, Carmel J. Sandhu, Shahneen Keerthikumar, Shivakumar Quezada Urban, Rosalia Papargiris, Melissa Kraska, Jenna Madsen, Heather B. Wang, Hong Richards, Michelle G. Niranjan, Birunthi O’Dea, Samantha Teng, Linda Wheelahan, William Li, Zhuoer Choo, Nicholas Ouyang, John F. Thorne, Heather Devereux, Lisa Hicks, Rodney J. Sengupta, Shomik Harewood, Laurence Iddawala, Mahesh Azad, Arun A. Goad, Jeremy Grummet, Jeremy Kourambas, John Kwan, Edmond M. Moon, Daniel Murphy, Declan G. Pedersen, John Clouston, David Norden, Sam Ryan, Andrew Furic, Luc Goode, David L. Frydenberg, Mark Lawrence, Mitchell G. Taylor, Renea A. |
| author_sort | Risbridger, Gail P. |
| collection | PubMed |
| description | Preclinical testing is a crucial step in evaluating cancer therapeutics. We aimed to establish a significant resource of patient-derived xenografts (PDXs) of prostate cancer for rapid and systematic evaluation of candidate therapies. The PDX collection comprises 59 tumors collected from 30 patients between 2012–2020, coinciding with availability of abiraterone and enzalutamide. The PDXs represent the clinico-pathological and genomic spectrum of prostate cancer, from treatment-naïve primary tumors to castration-resistant metastases. Inter- and intra-tumor heterogeneity in adenocarcinoma and neuroendocrine phenotypes is evident from bulk and single-cell RNA sequencing data. Organoids can be cultured from PDXs, providing further capabilities for preclinical studies. Using a 1 x 1 x 1 design, we rapidly identify tumors with exceptional responses to combination treatments. To govern the distribution of PDXs, we formed the Melbourne Urological Research Alliance (MURAL). This PDX collection is a substantial resource, expanding the capacity to test and prioritize effective treatments for prospective clinical trials in prostate cancer. |
| format | Online Article Text |
| id | pubmed-8376965 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-83769652021-09-02 The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology Risbridger, Gail P. Clark, Ashlee K. Porter, Laura H. Toivanen, Roxanne Bakshi, Andrew Lister, Natalie L. Pook, David Pezaro, Carmel J. Sandhu, Shahneen Keerthikumar, Shivakumar Quezada Urban, Rosalia Papargiris, Melissa Kraska, Jenna Madsen, Heather B. Wang, Hong Richards, Michelle G. Niranjan, Birunthi O’Dea, Samantha Teng, Linda Wheelahan, William Li, Zhuoer Choo, Nicholas Ouyang, John F. Thorne, Heather Devereux, Lisa Hicks, Rodney J. Sengupta, Shomik Harewood, Laurence Iddawala, Mahesh Azad, Arun A. Goad, Jeremy Grummet, Jeremy Kourambas, John Kwan, Edmond M. Moon, Daniel Murphy, Declan G. Pedersen, John Clouston, David Norden, Sam Ryan, Andrew Furic, Luc Goode, David L. Frydenberg, Mark Lawrence, Mitchell G. Taylor, Renea A. Nat Commun Article Preclinical testing is a crucial step in evaluating cancer therapeutics. We aimed to establish a significant resource of patient-derived xenografts (PDXs) of prostate cancer for rapid and systematic evaluation of candidate therapies. The PDX collection comprises 59 tumors collected from 30 patients between 2012–2020, coinciding with availability of abiraterone and enzalutamide. The PDXs represent the clinico-pathological and genomic spectrum of prostate cancer, from treatment-naïve primary tumors to castration-resistant metastases. Inter- and intra-tumor heterogeneity in adenocarcinoma and neuroendocrine phenotypes is evident from bulk and single-cell RNA sequencing data. Organoids can be cultured from PDXs, providing further capabilities for preclinical studies. Using a 1 x 1 x 1 design, we rapidly identify tumors with exceptional responses to combination treatments. To govern the distribution of PDXs, we formed the Melbourne Urological Research Alliance (MURAL). This PDX collection is a substantial resource, expanding the capacity to test and prioritize effective treatments for prospective clinical trials in prostate cancer. Nature Publishing Group UK 2021-08-19 /pmc/articles/PMC8376965/ /pubmed/34413304 http://dx.doi.org/10.1038/s41467-021-25175-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Risbridger, Gail P. Clark, Ashlee K. Porter, Laura H. Toivanen, Roxanne Bakshi, Andrew Lister, Natalie L. Pook, David Pezaro, Carmel J. Sandhu, Shahneen Keerthikumar, Shivakumar Quezada Urban, Rosalia Papargiris, Melissa Kraska, Jenna Madsen, Heather B. Wang, Hong Richards, Michelle G. Niranjan, Birunthi O’Dea, Samantha Teng, Linda Wheelahan, William Li, Zhuoer Choo, Nicholas Ouyang, John F. Thorne, Heather Devereux, Lisa Hicks, Rodney J. Sengupta, Shomik Harewood, Laurence Iddawala, Mahesh Azad, Arun A. Goad, Jeremy Grummet, Jeremy Kourambas, John Kwan, Edmond M. Moon, Daniel Murphy, Declan G. Pedersen, John Clouston, David Norden, Sam Ryan, Andrew Furic, Luc Goode, David L. Frydenberg, Mark Lawrence, Mitchell G. Taylor, Renea A. The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology |
| title | The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology |
| title_full | The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology |
| title_fullStr | The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology |
| title_full_unstemmed | The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology |
| title_short | The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology |
| title_sort | mural collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376965/ https://www.ncbi.nlm.nih.gov/pubmed/34413304 http://dx.doi.org/10.1038/s41467-021-25175-5 |
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