Cargando…

Sumoylation regulates the assembly and activity of the SMN complex

SMN is a ubiquitously expressed protein and is essential for life. SMN deficiency causes the neurodegenerative disease spinal muscular atrophy (SMA), the leading genetic cause of infant mortality. SMN interacts with itself and other proteins to form a complex that functions in the assembly of ribonu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Riboldi, Giulietta M., Faravelli, Irene, Kuwajima, Takaaki, Delestrée, Nicolas, Dermentzaki, Georgia, De Planell-Saguer, Mariangels, Rinchetti, Paola, Hao, Le Thi, Beattie, Christine C., Corti, Stefania, Przedborski, Serge, Mentis, George Z., Lotti, Francesco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376998/ https://www.ncbi.nlm.nih.gov/pubmed/34413305 http://dx.doi.org/10.1038/s41467-021-25272-5

Ejemplares similares

The SMN Complex at the Crossroad between RNA Metabolism and Neurodegeneration
por: Faravelli, Irene, et al.
Publicado: (2023)

SMN post-translational modifications in spinal muscular atrophy
por: Riboldi, Giulietta M., et al.
Publicado: (2023)

Retromer dysfunction in amyotrophic lateral sclerosis
por: Pérez-Torres, Eduardo J., et al.
Publicado: (2022)

Brain Calcifications: Genetic, Molecular, and Clinical Aspects
por: Monfrini, Edoardo, et al.
Publicado: (2023)

Gain of toxic function by long-term AAV9-mediated SMN overexpression in the sensory-motor circuit
por: Van Alstyne, Meaghan, et al.
Publicado: (2021)

New Insights on the Role of N(6)-Methyladenosine RNA Methylation in the Physiology and Pathology of the Nervous System
por: Dermentzaki, Georgia, et al.
Publicado: (2020)

Molecular, genetic and stem cell-mediated therapeutic strategies for spinal muscular atrophy (SMA)
por: Zanetta, Chiara, et al.
Publicado: (2014)

Motor neuron derivation from human embryonic and induced pluripotent stem cells: experimental approaches and clinical perspectives
por: Faravelli, Irene, et al.
Publicado: (2014)

Deletion of Ripk3 Prevents Motor Neuron Death In Vitro but not In Vivo
por: Dermentzaki, Georgia, et al.
Publicado: (2019)

Arginine methylation of Piwi proteins, catalyzed by dPRMT5, is required for Ago3 and Aub stability
por: Kirino, Yohei, et al.
Publicado: (2009)

Minimally invasive transplantation of iPSC-derived ALDHhiSSCloVLA4+ neural stem cells effectively improves the phenotype of an amyotrophic lateral sclerosis model
por: Nizzardo, Monica, et al.
Publicado: (2014)

SMN controls neuromuscular junction integrity through U7 snRNP
por: Tisdale, Sarah, et al.
Publicado: (2022)

Key role of SMN/SYNCRIP and RNA-Motif 7 in spinal muscular atrophy: RNA-Seq and motif analysis of human motor neurons
por: Rizzo, Federica, et al.
Publicado: (2019)

Growing Evidence about the Relationship between Vessel Dissection and Scuba Diving
por: Brajkovic, Simona, et al.
Publicado: (2013)

Cellular therapy to target neuroinflammation in amyotrophic lateral sclerosis
por: Rizzo, Federica, et al.
Publicado: (2013)

Direct reprogramming of human astrocytes into neural stem cells and neurons
por: Corti, Stefania, et al.
Publicado: (2012)

Exposure to NO(2), CO, and PM(2.5) is linked to regional DNA methylation differences in asthma
por: Prunicki, Mary, et al.
Publicado: (2018)

Clinical and molecular features and therapeutic perspectives of spinal muscular atrophy with respiratory distress type 1
por: Vanoli, Fiammetta, et al.
Publicado: (2015)

Physical activity, black carbon exposure, and DNA methylation in the FOXP3 promoter
por: Lovinsky-Desir, Stephanie, et al.
Publicado: (2017)

A Cell System for Phenotypic Screening of Modifiers of SMN2 Gene Expression and Function
por: Li, Darrick K., et al.
Publicado: (2013)

Molecular Crosstalk Between Non-SMN-Related and SMN-Related Spinal Muscular Atrophy
por: Šoltić, Darija, et al.
Publicado: (2020)

A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II
por: Liu, Yanli, et al.
Publicado: (2022)

Mitochondrial Fusion Proteins and Human Diseases
por: Ranieri, Michela, et al.
Publicado: (2013)

Generation and Characterization of a genetic zebrafish model of SMA carrying the human SMN2 gene
por: Hao, Le T, et al.
Publicado: (2011)

Alternative splicing of a cryptic exon embedded in intron 6 of SMN1 and SMN2
por: Yoshimoto, Satomi, et al.
Publicado: (2016)

CORRIGENDUM to Molecular Crosstalk Between Non-SMN-Related and SMN-Related Spinal Muscular Atrophy
Publicado: (2020)

The Need for SMN-Independent Treatments of Spinal Muscular Atrophy (SMA) to Complement SMN-Enhancing Drugs
por: Hensel, Niko, et al.
Publicado: (2020)

Preserving neuromuscular synapses in ALS by stimulating MuSK with a therapeutic agonist antibody
por: Cantor, Sarah, et al.
Publicado: (2018)

Normalization of Patient-Identified Plasma Biomarkers in SMNΔ7 Mice following Postnatal SMN Restoration
por: Arnold, W. David, et al.
Publicado: (2016)

Drug screening with human SMN2 reporter identifies SMN protein stabilizers to correct SMA pathology
por: Wang, Yiran, et al.
Publicado: (2019)

SMA-linked SMN mutants prevent phase separation properties and SMN interactions with FMRP family members
por: Binda, Olivier, et al.
Publicado: (2022)

The Frequency of SMN1, SMN2 Copy Numbers in 246 Turkish Cases Analyzed with MLPA Method
por: Yalcintepe, Sinem, et al.
Publicado: (2023)

The Role of Sumoylation in the Response to Hypoxia: An Overview
por: Filippopoulou, Chrysa, et al.
Publicado: (2020)

Systematic elucidation of neuron-astrocyte interaction in models of amyotrophic lateral sclerosis using multi-modal integrated bioinformatics workflow
por: Mishra, Vartika, et al.
Publicado: (2020)

Lysine-Less Variants of Spinal Muscular Atrophy SMN and SMNΔ7 Proteins Are Degraded by the Proteasome Pathway
por: Sánchez-Lanzas, Raúl, et al.
Publicado: (2017)

Axon outgrowth and neuronal differentiation defects after a-SMN and FL-SMN silencing in primary hippocampal cultures
por: Pletto, Daniela, et al.
Publicado: (2018)

Tyr78Phe Transthyretin Mutation with Predominant Motor Neuropathy as the Initial Presentation
por: Riboldi, Giulietta, et al.
Publicado: (2011)

Diagnostic Tips from a Video Series and Literature Review of Patients with Late-Onset Tay-Sachs Disease
por: Riboldi, Giulietta Maria, et al.
Publicado: (2022)

Letter response: Intra-familial phenotype variability in Late-Onset Tay-Sachs disease
por: Riboldi, Giulietta Maria, et al.
Publicado: (2023)

Absence of gemin5 from SMN complexes in nuclear Cajal bodies
por: Hao, Le thi, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_4sh2gu20hna7n5vdkc8b652r5g