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BMP antagonists in tissue development and disease

Bone morphogenic proteins (BMPs) are important growth regulators in embryogenesis and postnatal homeostasis. Their tight regulation is crucial for successful embryonic development as well as tissue homeostasis in the adult organism. BMP inhibition by natural extracellular biologic antagonists repres...

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Detalles Bibliográficos
Autores principales: Correns, Annkatrin, Zimmermann, Laura-Marie A., Baldock, Clair, Sengle, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377005/
https://www.ncbi.nlm.nih.gov/pubmed/34435185
http://dx.doi.org/10.1016/j.mbplus.2021.100071
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author Correns, Annkatrin
Zimmermann, Laura-Marie A.
Baldock, Clair
Sengle, Gerhard
author_facet Correns, Annkatrin
Zimmermann, Laura-Marie A.
Baldock, Clair
Sengle, Gerhard
author_sort Correns, Annkatrin
collection PubMed
description Bone morphogenic proteins (BMPs) are important growth regulators in embryogenesis and postnatal homeostasis. Their tight regulation is crucial for successful embryonic development as well as tissue homeostasis in the adult organism. BMP inhibition by natural extracellular biologic antagonists represents the most intensively studied mechanistic concept of BMP growth factor regulation. It was shown to be critical for numerous developmental programs, including germ layer specification and spatiotemporal gradients required for the establishment of the dorsal–ventral axis and organ formation. The importance of BMP antagonists for extracellular matrix homeostasis is illustrated by the numerous human connective tissue disorders caused by their mutational inactivation. Here, we will focus on the known functional interactions targeting BMP antagonists to the ECM and discuss how these interactions influence BMP antagonist activity. Moreover, we will provide an overview about the current concepts and investigated molecular mechanisms modulating BMP inhibitor function in the context of development and disease.
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spelling pubmed-83770052021-08-24 BMP antagonists in tissue development and disease Correns, Annkatrin Zimmermann, Laura-Marie A. Baldock, Clair Sengle, Gerhard Matrix Biol Plus Article Bone morphogenic proteins (BMPs) are important growth regulators in embryogenesis and postnatal homeostasis. Their tight regulation is crucial for successful embryonic development as well as tissue homeostasis in the adult organism. BMP inhibition by natural extracellular biologic antagonists represents the most intensively studied mechanistic concept of BMP growth factor regulation. It was shown to be critical for numerous developmental programs, including germ layer specification and spatiotemporal gradients required for the establishment of the dorsal–ventral axis and organ formation. The importance of BMP antagonists for extracellular matrix homeostasis is illustrated by the numerous human connective tissue disorders caused by their mutational inactivation. Here, we will focus on the known functional interactions targeting BMP antagonists to the ECM and discuss how these interactions influence BMP antagonist activity. Moreover, we will provide an overview about the current concepts and investigated molecular mechanisms modulating BMP inhibitor function in the context of development and disease. Elsevier 2021-06-11 /pmc/articles/PMC8377005/ /pubmed/34435185 http://dx.doi.org/10.1016/j.mbplus.2021.100071 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Correns, Annkatrin
Zimmermann, Laura-Marie A.
Baldock, Clair
Sengle, Gerhard
BMP antagonists in tissue development and disease
title BMP antagonists in tissue development and disease
title_full BMP antagonists in tissue development and disease
title_fullStr BMP antagonists in tissue development and disease
title_full_unstemmed BMP antagonists in tissue development and disease
title_short BMP antagonists in tissue development and disease
title_sort bmp antagonists in tissue development and disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377005/
https://www.ncbi.nlm.nih.gov/pubmed/34435185
http://dx.doi.org/10.1016/j.mbplus.2021.100071
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