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Different Gene Networks Are Disturbed by Zika Virus Infection in A Mouse Microcephaly Model

The association of Zika virus (ZIKV) infection with microcephaly has raised alarm worldwide. Their causal link has been confirmed in different animal models infected by ZIKV. However, the molecular mechanisms underlying ZIKV pathogenesis are far from clear. Hence, we performed global gene expression...

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Autores principales: Chang, Yafei, Jiang, Yisheng, Li, Cui, Wang, Qin, Zhang, Feng, Qin, Cheng-Feng, Wu, Qing-Feng, Li, Jing, Xu, Zhiheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377042/
https://www.ncbi.nlm.nih.gov/pubmed/33418086
http://dx.doi.org/10.1016/j.gpb.2019.06.004
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author Chang, Yafei
Jiang, Yisheng
Li, Cui
Wang, Qin
Zhang, Feng
Qin, Cheng-Feng
Wu, Qing-Feng
Li, Jing
Xu, Zhiheng
author_facet Chang, Yafei
Jiang, Yisheng
Li, Cui
Wang, Qin
Zhang, Feng
Qin, Cheng-Feng
Wu, Qing-Feng
Li, Jing
Xu, Zhiheng
author_sort Chang, Yafei
collection PubMed
description The association of Zika virus (ZIKV) infection with microcephaly has raised alarm worldwide. Their causal link has been confirmed in different animal models infected by ZIKV. However, the molecular mechanisms underlying ZIKV pathogenesis are far from clear. Hence, we performed global gene expression analysis of ZIKV-infected mouse brains to unveil the biological and molecular networks underpinning microcephaly. We found significant dysregulation of the sub-networks associated with brain development, immune response, cell death, microglial cell activation, and autophagy amongst others. We provided detailed analysis of the related complicated gene networks and the links between them. Additionally, we analyzed the signaling pathways that were likely to be involved. This report provides systemic insights into not only the pathogenesis, but also a path to the development of prophylactic and therapeutic strategies against ZIKV infection.
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spelling pubmed-83770422021-08-24 Different Gene Networks Are Disturbed by Zika Virus Infection in A Mouse Microcephaly Model Chang, Yafei Jiang, Yisheng Li, Cui Wang, Qin Zhang, Feng Qin, Cheng-Feng Wu, Qing-Feng Li, Jing Xu, Zhiheng Genomics Proteomics Bioinformatics Letter The association of Zika virus (ZIKV) infection with microcephaly has raised alarm worldwide. Their causal link has been confirmed in different animal models infected by ZIKV. However, the molecular mechanisms underlying ZIKV pathogenesis are far from clear. Hence, we performed global gene expression analysis of ZIKV-infected mouse brains to unveil the biological and molecular networks underpinning microcephaly. We found significant dysregulation of the sub-networks associated with brain development, immune response, cell death, microglial cell activation, and autophagy amongst others. We provided detailed analysis of the related complicated gene networks and the links between them. Additionally, we analyzed the signaling pathways that were likely to be involved. This report provides systemic insights into not only the pathogenesis, but also a path to the development of prophylactic and therapeutic strategies against ZIKV infection. Elsevier 2020-12 2021-01-06 /pmc/articles/PMC8377042/ /pubmed/33418086 http://dx.doi.org/10.1016/j.gpb.2019.06.004 Text en © 2021 Beijing Institute of Genomics, Chinese Academy of Sciences and Genetics Society of China https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Letter
Chang, Yafei
Jiang, Yisheng
Li, Cui
Wang, Qin
Zhang, Feng
Qin, Cheng-Feng
Wu, Qing-Feng
Li, Jing
Xu, Zhiheng
Different Gene Networks Are Disturbed by Zika Virus Infection in A Mouse Microcephaly Model
title Different Gene Networks Are Disturbed by Zika Virus Infection in A Mouse Microcephaly Model
title_full Different Gene Networks Are Disturbed by Zika Virus Infection in A Mouse Microcephaly Model
title_fullStr Different Gene Networks Are Disturbed by Zika Virus Infection in A Mouse Microcephaly Model
title_full_unstemmed Different Gene Networks Are Disturbed by Zika Virus Infection in A Mouse Microcephaly Model
title_short Different Gene Networks Are Disturbed by Zika Virus Infection in A Mouse Microcephaly Model
title_sort different gene networks are disturbed by zika virus infection in a mouse microcephaly model
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377042/
https://www.ncbi.nlm.nih.gov/pubmed/33418086
http://dx.doi.org/10.1016/j.gpb.2019.06.004
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