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How Early-Life Gut Microbiota Alteration Sets Trajectories for Health and Inflammatory Bowel Disease?
Inflammatory bowel disease (IBD) is a recurrent chronic inflammatory condition of the intestine without any efficient therapeutic regimens. Gut microbiota, which plays an instrumental role in the development and maturation of the immune system, has been implicated in the pathogenesis of IBD. Emergin...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377158/ https://www.ncbi.nlm.nih.gov/pubmed/34422881 http://dx.doi.org/10.3389/fnut.2021.690073 |
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author | Guo, Feilong Cai, Demin Li, Yanwei Gu, Haotian Qu, Huan Zong, Qiufang Bao, Wenbin Chen, Aoxue Liu, Hao-Yu |
author_facet | Guo, Feilong Cai, Demin Li, Yanwei Gu, Haotian Qu, Huan Zong, Qiufang Bao, Wenbin Chen, Aoxue Liu, Hao-Yu |
author_sort | Guo, Feilong |
collection | PubMed |
description | Inflammatory bowel disease (IBD) is a recurrent chronic inflammatory condition of the intestine without any efficient therapeutic regimens. Gut microbiota, which plays an instrumental role in the development and maturation of the immune system, has been implicated in the pathogenesis of IBD. Emerging evidence has established that early-life events particularly maternal influences and antibiotic treatment are strongly correlated with the health or susceptibility to disease of an individual in later life. Thus, it is proposed that there is a critical period in infancy, during which the environmental exposures bestow a long-term pathophysiological imprint. This notion sheds new light on the development of novel approaches for the treatment, i.e., early interventions, more precisely, the prevention of many uncurable chronic inflammatory diseases like IBD. In this review, we have integrated current evidence to describe the feasibility of the “able-to-be-regulated microbiota,” summarized the underlying mechanisms of the “microbiota-driven immune system education,” explored the optimal intervention time window, and discussed the potential of designing early-probiotic treatment as a new prevention strategy for IBD. |
format | Online Article Text |
id | pubmed-8377158 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83771582021-08-21 How Early-Life Gut Microbiota Alteration Sets Trajectories for Health and Inflammatory Bowel Disease? Guo, Feilong Cai, Demin Li, Yanwei Gu, Haotian Qu, Huan Zong, Qiufang Bao, Wenbin Chen, Aoxue Liu, Hao-Yu Front Nutr Nutrition Inflammatory bowel disease (IBD) is a recurrent chronic inflammatory condition of the intestine without any efficient therapeutic regimens. Gut microbiota, which plays an instrumental role in the development and maturation of the immune system, has been implicated in the pathogenesis of IBD. Emerging evidence has established that early-life events particularly maternal influences and antibiotic treatment are strongly correlated with the health or susceptibility to disease of an individual in later life. Thus, it is proposed that there is a critical period in infancy, during which the environmental exposures bestow a long-term pathophysiological imprint. This notion sheds new light on the development of novel approaches for the treatment, i.e., early interventions, more precisely, the prevention of many uncurable chronic inflammatory diseases like IBD. In this review, we have integrated current evidence to describe the feasibility of the “able-to-be-regulated microbiota,” summarized the underlying mechanisms of the “microbiota-driven immune system education,” explored the optimal intervention time window, and discussed the potential of designing early-probiotic treatment as a new prevention strategy for IBD. Frontiers Media S.A. 2021-08-06 /pmc/articles/PMC8377158/ /pubmed/34422881 http://dx.doi.org/10.3389/fnut.2021.690073 Text en Copyright © 2021 Guo, Cai, Li, Gu, Qu, Zong, Bao, Chen and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Guo, Feilong Cai, Demin Li, Yanwei Gu, Haotian Qu, Huan Zong, Qiufang Bao, Wenbin Chen, Aoxue Liu, Hao-Yu How Early-Life Gut Microbiota Alteration Sets Trajectories for Health and Inflammatory Bowel Disease? |
title | How Early-Life Gut Microbiota Alteration Sets Trajectories for Health and Inflammatory Bowel Disease? |
title_full | How Early-Life Gut Microbiota Alteration Sets Trajectories for Health and Inflammatory Bowel Disease? |
title_fullStr | How Early-Life Gut Microbiota Alteration Sets Trajectories for Health and Inflammatory Bowel Disease? |
title_full_unstemmed | How Early-Life Gut Microbiota Alteration Sets Trajectories for Health and Inflammatory Bowel Disease? |
title_short | How Early-Life Gut Microbiota Alteration Sets Trajectories for Health and Inflammatory Bowel Disease? |
title_sort | how early-life gut microbiota alteration sets trajectories for health and inflammatory bowel disease? |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377158/ https://www.ncbi.nlm.nih.gov/pubmed/34422881 http://dx.doi.org/10.3389/fnut.2021.690073 |
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