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How Early-Life Gut Microbiota Alteration Sets Trajectories for Health and Inflammatory Bowel Disease?

Inflammatory bowel disease (IBD) is a recurrent chronic inflammatory condition of the intestine without any efficient therapeutic regimens. Gut microbiota, which plays an instrumental role in the development and maturation of the immune system, has been implicated in the pathogenesis of IBD. Emergin...

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Autores principales: Guo, Feilong, Cai, Demin, Li, Yanwei, Gu, Haotian, Qu, Huan, Zong, Qiufang, Bao, Wenbin, Chen, Aoxue, Liu, Hao-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377158/
https://www.ncbi.nlm.nih.gov/pubmed/34422881
http://dx.doi.org/10.3389/fnut.2021.690073
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author Guo, Feilong
Cai, Demin
Li, Yanwei
Gu, Haotian
Qu, Huan
Zong, Qiufang
Bao, Wenbin
Chen, Aoxue
Liu, Hao-Yu
author_facet Guo, Feilong
Cai, Demin
Li, Yanwei
Gu, Haotian
Qu, Huan
Zong, Qiufang
Bao, Wenbin
Chen, Aoxue
Liu, Hao-Yu
author_sort Guo, Feilong
collection PubMed
description Inflammatory bowel disease (IBD) is a recurrent chronic inflammatory condition of the intestine without any efficient therapeutic regimens. Gut microbiota, which plays an instrumental role in the development and maturation of the immune system, has been implicated in the pathogenesis of IBD. Emerging evidence has established that early-life events particularly maternal influences and antibiotic treatment are strongly correlated with the health or susceptibility to disease of an individual in later life. Thus, it is proposed that there is a critical period in infancy, during which the environmental exposures bestow a long-term pathophysiological imprint. This notion sheds new light on the development of novel approaches for the treatment, i.e., early interventions, more precisely, the prevention of many uncurable chronic inflammatory diseases like IBD. In this review, we have integrated current evidence to describe the feasibility of the “able-to-be-regulated microbiota,” summarized the underlying mechanisms of the “microbiota-driven immune system education,” explored the optimal intervention time window, and discussed the potential of designing early-probiotic treatment as a new prevention strategy for IBD.
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spelling pubmed-83771582021-08-21 How Early-Life Gut Microbiota Alteration Sets Trajectories for Health and Inflammatory Bowel Disease? Guo, Feilong Cai, Demin Li, Yanwei Gu, Haotian Qu, Huan Zong, Qiufang Bao, Wenbin Chen, Aoxue Liu, Hao-Yu Front Nutr Nutrition Inflammatory bowel disease (IBD) is a recurrent chronic inflammatory condition of the intestine without any efficient therapeutic regimens. Gut microbiota, which plays an instrumental role in the development and maturation of the immune system, has been implicated in the pathogenesis of IBD. Emerging evidence has established that early-life events particularly maternal influences and antibiotic treatment are strongly correlated with the health or susceptibility to disease of an individual in later life. Thus, it is proposed that there is a critical period in infancy, during which the environmental exposures bestow a long-term pathophysiological imprint. This notion sheds new light on the development of novel approaches for the treatment, i.e., early interventions, more precisely, the prevention of many uncurable chronic inflammatory diseases like IBD. In this review, we have integrated current evidence to describe the feasibility of the “able-to-be-regulated microbiota,” summarized the underlying mechanisms of the “microbiota-driven immune system education,” explored the optimal intervention time window, and discussed the potential of designing early-probiotic treatment as a new prevention strategy for IBD. Frontiers Media S.A. 2021-08-06 /pmc/articles/PMC8377158/ /pubmed/34422881 http://dx.doi.org/10.3389/fnut.2021.690073 Text en Copyright © 2021 Guo, Cai, Li, Gu, Qu, Zong, Bao, Chen and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Guo, Feilong
Cai, Demin
Li, Yanwei
Gu, Haotian
Qu, Huan
Zong, Qiufang
Bao, Wenbin
Chen, Aoxue
Liu, Hao-Yu
How Early-Life Gut Microbiota Alteration Sets Trajectories for Health and Inflammatory Bowel Disease?
title How Early-Life Gut Microbiota Alteration Sets Trajectories for Health and Inflammatory Bowel Disease?
title_full How Early-Life Gut Microbiota Alteration Sets Trajectories for Health and Inflammatory Bowel Disease?
title_fullStr How Early-Life Gut Microbiota Alteration Sets Trajectories for Health and Inflammatory Bowel Disease?
title_full_unstemmed How Early-Life Gut Microbiota Alteration Sets Trajectories for Health and Inflammatory Bowel Disease?
title_short How Early-Life Gut Microbiota Alteration Sets Trajectories for Health and Inflammatory Bowel Disease?
title_sort how early-life gut microbiota alteration sets trajectories for health and inflammatory bowel disease?
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377158/
https://www.ncbi.nlm.nih.gov/pubmed/34422881
http://dx.doi.org/10.3389/fnut.2021.690073
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