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Inhibition of Rac1 GTPase Decreases Vascular Oxidative Stress, Improves Endothelial Function, and Attenuates Atherosclerosis Development in Mice

Aims: Oxidative stress and inflammation contribute to atherogenesis. Rac1 GTPase regulates pro-oxidant NADPH oxidase activity, reactive oxygen species (ROS) formation, actin cytoskeleton organization and monocyte adhesion. We investigated the vascular effects of pharmacological inhibition of Rac1 GT...

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Detalles Bibliográficos
Autores principales:	Zimmer, Sebastian, Goody, Philip Roger, Oelze, Matthias, Ghanem, Alexander, Mueller, Cornelius F., Laufs, Ulrich, Daiber, Andreas, Jansen, Felix, Nickenig, Georg, Wassmann, Sven
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cardiovascular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377253/ https://www.ncbi.nlm.nih.gov/pubmed/34422919 http://dx.doi.org/10.3389/fcvm.2021.680775

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