Immune Microenvironment Change and Involvement of Circular RNAs in TIL Cells of Recurrent Nasopharyngeal Carcinoma

Nasopharyngeal carcinoma is a malignant tumor that is highly prevalent in southern China and the Southeast Asian belt. Recent studies have shown that the T cells play important regulatory roles in tumorigenesis and progression. We test TIL cell of recurrent nasopharyngeal carcinoma and primary nasop...

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Autores principales: Wang, Yumin, Peng, Zhouying, Wang, Yaxuan, Yang, Yi, Fan, Ruohao, Gao, Kelei, Zhang, Hua, Xie, Zhihai, Jiang, Weihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377430/
https://www.ncbi.nlm.nih.gov/pubmed/34422839
http://dx.doi.org/10.3389/fcell.2021.722224
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author Wang, Yumin
Peng, Zhouying
Wang, Yaxuan
Yang, Yi
Fan, Ruohao
Gao, Kelei
Zhang, Hua
Xie, Zhihai
Jiang, Weihong
author_facet Wang, Yumin
Peng, Zhouying
Wang, Yaxuan
Yang, Yi
Fan, Ruohao
Gao, Kelei
Zhang, Hua
Xie, Zhihai
Jiang, Weihong
author_sort Wang, Yumin
collection PubMed
description Nasopharyngeal carcinoma is a malignant tumor that is highly prevalent in southern China and the Southeast Asian belt. Recent studies have shown that the T cells play important regulatory roles in tumorigenesis and progression. We test TIL cell of recurrent nasopharyngeal carcinoma and primary nasopharyngeal carcinoma cell. We found that T cell change in recurrent nasopharyngeal carcinoma and primary nasopharyngeal carcinoma cell. Based on GEO database, we selected differently expressed circRNAs in nasopharyngeal carcinoma tissues. qRTPCR show that some circRNAs also highly expressed in TIL cells. In conclusion, immune microenvironment changed in recurrent nasopharyngeal carcinoma. There is involvement of circular RNAs in this progress, with should be researched further.
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spelling pubmed-83774302021-08-21 Immune Microenvironment Change and Involvement of Circular RNAs in TIL Cells of Recurrent Nasopharyngeal Carcinoma Wang, Yumin Peng, Zhouying Wang, Yaxuan Yang, Yi Fan, Ruohao Gao, Kelei Zhang, Hua Xie, Zhihai Jiang, Weihong Front Cell Dev Biol Cell and Developmental Biology Nasopharyngeal carcinoma is a malignant tumor that is highly prevalent in southern China and the Southeast Asian belt. Recent studies have shown that the T cells play important regulatory roles in tumorigenesis and progression. We test TIL cell of recurrent nasopharyngeal carcinoma and primary nasopharyngeal carcinoma cell. We found that T cell change in recurrent nasopharyngeal carcinoma and primary nasopharyngeal carcinoma cell. Based on GEO database, we selected differently expressed circRNAs in nasopharyngeal carcinoma tissues. qRTPCR show that some circRNAs also highly expressed in TIL cells. In conclusion, immune microenvironment changed in recurrent nasopharyngeal carcinoma. There is involvement of circular RNAs in this progress, with should be researched further. Frontiers Media S.A. 2021-08-06 /pmc/articles/PMC8377430/ /pubmed/34422839 http://dx.doi.org/10.3389/fcell.2021.722224 Text en Copyright © 2021 Wang, Peng, Wang, Yang, Fan, Gao, Zhang, Xie and Jiang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Wang, Yumin
Peng, Zhouying
Wang, Yaxuan
Yang, Yi
Fan, Ruohao
Gao, Kelei
Zhang, Hua
Xie, Zhihai
Jiang, Weihong
Immune Microenvironment Change and Involvement of Circular RNAs in TIL Cells of Recurrent Nasopharyngeal Carcinoma
title Immune Microenvironment Change and Involvement of Circular RNAs in TIL Cells of Recurrent Nasopharyngeal Carcinoma
title_full Immune Microenvironment Change and Involvement of Circular RNAs in TIL Cells of Recurrent Nasopharyngeal Carcinoma
title_fullStr Immune Microenvironment Change and Involvement of Circular RNAs in TIL Cells of Recurrent Nasopharyngeal Carcinoma
title_full_unstemmed Immune Microenvironment Change and Involvement of Circular RNAs in TIL Cells of Recurrent Nasopharyngeal Carcinoma
title_short Immune Microenvironment Change and Involvement of Circular RNAs in TIL Cells of Recurrent Nasopharyngeal Carcinoma
title_sort immune microenvironment change and involvement of circular rnas in til cells of recurrent nasopharyngeal carcinoma
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377430/
https://www.ncbi.nlm.nih.gov/pubmed/34422839
http://dx.doi.org/10.3389/fcell.2021.722224
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