The Effects of NT-1044, a Novel AMPK Activator, on Endometrial Cancer Cell Proliferation, Apoptosis, Cell Stress and In Vivo Tumor Growth

OBJECTIVES: Anti-diabetic biguanide drugs such as metformin may have anti-tumorigenic effects by behaving as AMPK activators and mTOR inhibitors. Metformin requires organic cation transporters (OCTs) for entry into cells, and NT-1044 is an AMPK activator designed to have greater affinity for two of...

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Detalles Bibliográficos
Autores principales: Roque, Dario R., Zhang, Lu, Wysham, Weiya Z., Han, Jianjun, Sun, Wenchuan, Yin, Yajie, Livingston, James N., Batchelor, Ken W., Zhou, Chunxiao, Bae-Jump, Victoria L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377676/
https://www.ncbi.nlm.nih.gov/pubmed/34422646
http://dx.doi.org/10.3389/fonc.2021.690435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377676/
https://www.ncbi.nlm.nih.gov/pubmed/34422646
http://dx.doi.org/10.3389/fonc.2021.690435

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