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Association of walking energetics with amyloid beta status: Findings from the Baltimore Longitudinal Study of Aging

INTRODUCTION: Higher energetic costs for mobility predict gait speed decline. Slow gait is linked to cognitive decline and Alzheimer's disease (AD). Whether the energetic cost of walking is linked to AD pathology is unknown. We investigated the cross‐sectional association between the energetic...

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Autores principales: Dougherty, Ryan J., Ramachandran, Janani, Liu, Fangyu, An, Yang, Wanigatunga, Amal A., Tian, Qu, Bilgel, Murat, Simonsick, Eleanor M., Ferrucci, Luigi, Resnick, Susan M., Schrack, Jennifer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377776/
https://www.ncbi.nlm.nih.gov/pubmed/34458552
http://dx.doi.org/10.1002/dad2.12228
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author Dougherty, Ryan J.
Ramachandran, Janani
Liu, Fangyu
An, Yang
Wanigatunga, Amal A.
Tian, Qu
Bilgel, Murat
Simonsick, Eleanor M.
Ferrucci, Luigi
Resnick, Susan M.
Schrack, Jennifer A.
author_facet Dougherty, Ryan J.
Ramachandran, Janani
Liu, Fangyu
An, Yang
Wanigatunga, Amal A.
Tian, Qu
Bilgel, Murat
Simonsick, Eleanor M.
Ferrucci, Luigi
Resnick, Susan M.
Schrack, Jennifer A.
author_sort Dougherty, Ryan J.
collection PubMed
description INTRODUCTION: Higher energetic costs for mobility predict gait speed decline. Slow gait is linked to cognitive decline and Alzheimer's disease (AD). Whether the energetic cost of walking is linked to AD pathology is unknown. We investigated the cross‐sectional association between the energetic cost of walking, gait speed, and amyloid beta (Aβ) status (+/−) in older adults. METHODS: One hundred forty‐nine cognitively normal adults (56% women, mean age 77.5 ± 8.4 years) completed customary‐paced walking assessments with indirect calorimetry and (11)C‐Pittsburgh compound B positron emission tomography. Logistic regression models examined associations adjusted for demographics, body composition, comorbid conditions, and apolipoprotein E ε4. RESULTS: Each 0.01 mL/kg/m greater energy cost was associated with 18% higher odds of being Aβ+ (odds ratio [OR] = 1.18; 95% confidence interval [CI]: 1.04 to 1.34; P = .011). These findings were not observed when investigating gait speed (OR = 0.99; 95% CI: 0.97 to 1.01; P = .321). DISCUSSION: High energetic cost of walking is linked to AD pathology and may be a potential target for therapeutic intervention.
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spelling pubmed-83777762021-08-27 Association of walking energetics with amyloid beta status: Findings from the Baltimore Longitudinal Study of Aging Dougherty, Ryan J. Ramachandran, Janani Liu, Fangyu An, Yang Wanigatunga, Amal A. Tian, Qu Bilgel, Murat Simonsick, Eleanor M. Ferrucci, Luigi Resnick, Susan M. Schrack, Jennifer A. Alzheimers Dement (Amst) Cognitive & Behavioral Assessment INTRODUCTION: Higher energetic costs for mobility predict gait speed decline. Slow gait is linked to cognitive decline and Alzheimer's disease (AD). Whether the energetic cost of walking is linked to AD pathology is unknown. We investigated the cross‐sectional association between the energetic cost of walking, gait speed, and amyloid beta (Aβ) status (+/−) in older adults. METHODS: One hundred forty‐nine cognitively normal adults (56% women, mean age 77.5 ± 8.4 years) completed customary‐paced walking assessments with indirect calorimetry and (11)C‐Pittsburgh compound B positron emission tomography. Logistic regression models examined associations adjusted for demographics, body composition, comorbid conditions, and apolipoprotein E ε4. RESULTS: Each 0.01 mL/kg/m greater energy cost was associated with 18% higher odds of being Aβ+ (odds ratio [OR] = 1.18; 95% confidence interval [CI]: 1.04 to 1.34; P = .011). These findings were not observed when investigating gait speed (OR = 0.99; 95% CI: 0.97 to 1.01; P = .321). DISCUSSION: High energetic cost of walking is linked to AD pathology and may be a potential target for therapeutic intervention. John Wiley and Sons Inc. 2021-08-20 /pmc/articles/PMC8377776/ /pubmed/34458552 http://dx.doi.org/10.1002/dad2.12228 Text en © 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Cognitive & Behavioral Assessment
Dougherty, Ryan J.
Ramachandran, Janani
Liu, Fangyu
An, Yang
Wanigatunga, Amal A.
Tian, Qu
Bilgel, Murat
Simonsick, Eleanor M.
Ferrucci, Luigi
Resnick, Susan M.
Schrack, Jennifer A.
Association of walking energetics with amyloid beta status: Findings from the Baltimore Longitudinal Study of Aging
title Association of walking energetics with amyloid beta status: Findings from the Baltimore Longitudinal Study of Aging
title_full Association of walking energetics with amyloid beta status: Findings from the Baltimore Longitudinal Study of Aging
title_fullStr Association of walking energetics with amyloid beta status: Findings from the Baltimore Longitudinal Study of Aging
title_full_unstemmed Association of walking energetics with amyloid beta status: Findings from the Baltimore Longitudinal Study of Aging
title_short Association of walking energetics with amyloid beta status: Findings from the Baltimore Longitudinal Study of Aging
title_sort association of walking energetics with amyloid beta status: findings from the baltimore longitudinal study of aging
topic Cognitive & Behavioral Assessment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377776/
https://www.ncbi.nlm.nih.gov/pubmed/34458552
http://dx.doi.org/10.1002/dad2.12228
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