N(6)-methyladenosine-modified circIGF2BP3 inhibits CD8(+) T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer

BACKGROUND: An in-depth understanding of immune evasion mechanisms in tumors is crucial to overcome resistance and enable innovative advances in immunotherapy. Circular RNAs (circRNAs) have been implicated in cancer progression. However, much remains unknown regarding whether circRNAs impact immune...

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Detalles Bibliográficos
Autores principales: Liu, Zhenchuan, Wang, Tingting, She, Yunlang, Wu, Kaiqing, Gu, Shaorui, Li, Lei, Dong, Chenglai, Chen, Chang, Zhou, Yongxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377850/
https://www.ncbi.nlm.nih.gov/pubmed/34416901
http://dx.doi.org/10.1186/s12943-021-01398-4

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