Effective control of large deletions after double-strand breaks by homology-directed repair and dsODN insertion

BACKGROUND: After repairing double-strand breaks (DSBs) caused by CRISPR-Cas9 cleavage, genomic damage, such as large deletions, may have pathogenic consequences. RESULTS: We show that large deletions are ubiquitous but are dependent on editing sites and cell types. Human primary T cells display mor...

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Detalles Bibliográficos
Autores principales: Wen, Wei, Quan, Zi-Jun, Li, Si-Ang, Yang, Zhi-Xue, Fu, Ya-Wen, Zhang, Feng, Li, Guo-Hua, Zhao, Mei, Yin, Meng-Di, Xu, Jing, Zhang, Jian-Ping, Cheng, Tao, Zhang, Xiao-Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377869/
https://www.ncbi.nlm.nih.gov/pubmed/34416913
http://dx.doi.org/10.1186/s13059-021-02462-4

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