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Effect of Intensity Modulated Radiotherapy (IMRT) on the immunity, physical status and clinical effect of locally advanced NSCLC patients

OBJECTIVES: To evaluate the clinical value of radiotherapy combined with Camrelizumab in treating locally advanced non-small cell lung cancer (NSCLC) patients. METHODS: 80 locally advanced NSCLC patients were randomly divided into two groups (n=40). The control group was administered with intensity...

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Autor principal: Xu, Jun-kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377908/
https://www.ncbi.nlm.nih.gov/pubmed/34475934
http://dx.doi.org/10.12669/pjms.37.5.4188
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author Xu, Jun-kai
author_facet Xu, Jun-kai
author_sort Xu, Jun-kai
collection PubMed
description OBJECTIVES: To evaluate the clinical value of radiotherapy combined with Camrelizumab in treating locally advanced non-small cell lung cancer (NSCLC) patients. METHODS: 80 locally advanced NSCLC patients were randomly divided into two groups (n=40). The control group was administered with intensity modulated radiation therapy (IMRT), whereas the experimental group with Camrelizumab in addition to IMRT. All the patients underwent clinical efficacy evaluation in terms of adverse drug reaction (ADR), physical status improvement after the treatment, and changes in T lymphocyte subpopulations (incl. CD3(+), CD4(+), CD8(+), CD4(+)/CD8(+)). RESULTS: The efficacy was found to be 70% and 47.5 in experimental group and control group, respectively, with the former being significantly better than the latter (p=0.03). The ADR rates were 50% and 37.5% in the experimental group and control group, respectively; but the difference remained insignificant (p=0.26). As for physical status improvement, experimental group evidently excelled the control group (p=0.04). The post-treatment indicators such as CD3(+), CD4(+), CD8(+), CD4(+)/CD8(+) were significantly more improved in the experimental group than the control group (CD3(+), p=0.02; CD4(+), p=0.00; and CD4(+)/CD8(+), p=0.01). However, the changes in CD8+ were not significant at all (p=0.46). CONCLUSIONS: The combined therapy of IMRT with Camrelizumab appeared effective in dealing with the locally advanced NSCLC patients, as such patients presented significantly better immune state and physical status improvement but not increased ADR. The therapy is both safe and effective.
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spelling pubmed-83779082021-09-01 Effect of Intensity Modulated Radiotherapy (IMRT) on the immunity, physical status and clinical effect of locally advanced NSCLC patients Xu, Jun-kai Pak J Med Sci Original Article OBJECTIVES: To evaluate the clinical value of radiotherapy combined with Camrelizumab in treating locally advanced non-small cell lung cancer (NSCLC) patients. METHODS: 80 locally advanced NSCLC patients were randomly divided into two groups (n=40). The control group was administered with intensity modulated radiation therapy (IMRT), whereas the experimental group with Camrelizumab in addition to IMRT. All the patients underwent clinical efficacy evaluation in terms of adverse drug reaction (ADR), physical status improvement after the treatment, and changes in T lymphocyte subpopulations (incl. CD3(+), CD4(+), CD8(+), CD4(+)/CD8(+)). RESULTS: The efficacy was found to be 70% and 47.5 in experimental group and control group, respectively, with the former being significantly better than the latter (p=0.03). The ADR rates were 50% and 37.5% in the experimental group and control group, respectively; but the difference remained insignificant (p=0.26). As for physical status improvement, experimental group evidently excelled the control group (p=0.04). The post-treatment indicators such as CD3(+), CD4(+), CD8(+), CD4(+)/CD8(+) were significantly more improved in the experimental group than the control group (CD3(+), p=0.02; CD4(+), p=0.00; and CD4(+)/CD8(+), p=0.01). However, the changes in CD8+ were not significant at all (p=0.46). CONCLUSIONS: The combined therapy of IMRT with Camrelizumab appeared effective in dealing with the locally advanced NSCLC patients, as such patients presented significantly better immune state and physical status improvement but not increased ADR. The therapy is both safe and effective. Professional Medical Publications 2021 /pmc/articles/PMC8377908/ /pubmed/34475934 http://dx.doi.org/10.12669/pjms.37.5.4188 Text en Copyright: © Pakistan Journal of Medical Sciences https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0 (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Xu, Jun-kai
Effect of Intensity Modulated Radiotherapy (IMRT) on the immunity, physical status and clinical effect of locally advanced NSCLC patients
title Effect of Intensity Modulated Radiotherapy (IMRT) on the immunity, physical status and clinical effect of locally advanced NSCLC patients
title_full Effect of Intensity Modulated Radiotherapy (IMRT) on the immunity, physical status and clinical effect of locally advanced NSCLC patients
title_fullStr Effect of Intensity Modulated Radiotherapy (IMRT) on the immunity, physical status and clinical effect of locally advanced NSCLC patients
title_full_unstemmed Effect of Intensity Modulated Radiotherapy (IMRT) on the immunity, physical status and clinical effect of locally advanced NSCLC patients
title_short Effect of Intensity Modulated Radiotherapy (IMRT) on the immunity, physical status and clinical effect of locally advanced NSCLC patients
title_sort effect of intensity modulated radiotherapy (imrt) on the immunity, physical status and clinical effect of locally advanced nsclc patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377908/
https://www.ncbi.nlm.nih.gov/pubmed/34475934
http://dx.doi.org/10.12669/pjms.37.5.4188
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