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Hyaluronic acid synthesis, degradation, and crosslinking in equine osteoarthritis: TNF-α-TSG-6-mediated HC-HA formation

BACKGROUND: TNF-α-stimulated gene 6 (TSG-6) protein, a TNF-α-responsive hyaladherin, possesses enzymatic activity that can catalyze covalent crosslinks of the polysaccharide hyaluronic acid (HA) to another protein to form heavy chain-hyaluronic acid (HC-HA) complexes in pathological conditions such...

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Detalles Bibliográficos
Autores principales:	Fasanello, Diana C., Su, Jin, Deng, Siyu, Yin, Rose, Colville, Marshall J., Berenson, Joshua M., Kelly, Carolyn M., Freer, Heather, Rollins, Alicia, Wagner, Bettina, Rivas, Felipe, Hall, Adam R., Rahbar, Elaheh, DeAngelis, Paul L., Paszek, Matthew J., Reesink, Heidi L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377964/ https://www.ncbi.nlm.nih.gov/pubmed/34416923 http://dx.doi.org/10.1186/s13075-021-02588-7

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