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Neurodevelopmental profiles of preschool-age children in Flint, Michigan: a latent profile analysis

OBJECTIVE: Children in Flint, Michigan, have experienced myriad sociodemographic adversities exacerbated by the Flint water crisis. To help inform child-focused prevention and intervention efforts, we aimed to describe patterns of neurodevelopmental outcomes among preschoolers who experienced the Fl...

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Autores principales: Zheng, Shuting, Bishop, Somer L., Ceja, Tiffany, Hanna-Attisha, Mona, LeWinn, Kaja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377967/
https://www.ncbi.nlm.nih.gov/pubmed/34412591
http://dx.doi.org/10.1186/s11689-021-09377-y
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author Zheng, Shuting
Bishop, Somer L.
Ceja, Tiffany
Hanna-Attisha, Mona
LeWinn, Kaja
author_facet Zheng, Shuting
Bishop, Somer L.
Ceja, Tiffany
Hanna-Attisha, Mona
LeWinn, Kaja
author_sort Zheng, Shuting
collection PubMed
description OBJECTIVE: Children in Flint, Michigan, have experienced myriad sociodemographic adversities exacerbated by the Flint water crisis. To help inform child-focused prevention and intervention efforts, we aimed to describe patterns of neurodevelopmental outcomes among preschoolers who experienced the Flint water crisis before age 2 years. METHOD: Participants were 170 preschoolers who completed a comprehensive neurodevelopmental assessment battery, including directly administered measures of cognitive and executive functioning and maternal-report of adaptive skills and behavioral problems. We used latent profile analysis to derive subgroups. Multivariate multinomial logistic regression was conducted to examine the predictors of profile memberships, including child sex and maternal/family-level factors selected from an array of measured exposures using least absolute shrinkage and selection operator regression. RESULTS: Three latent profiles were identified: Profile 1—relative weakness in all domains (50%); Profile 2—normative functioning in all domains (34.1%); and Profile 3—relative strengths in executive function and behavior (15.9%). Profile 1 showed lower scores across cognitive and behavioral domains. Profile 2 demonstrated abilities within the normal range across domains. Profile 3 showed relative strength in executive functioning with few behavior problems, despite lower cognitive performance. Children across all profiles showed adaptive behavior in the adequate range. Child sex and maternal IQ were significant predictors of profile membership. CONCLUSIONS: Children in Flint demonstrated diverse patterns of development in the face of sociodemographic and environmental adversities. Comprehensive screening and neurodevelopmental profiling of children in this at-risk population are needed to identify areas of needs and inform appropriate service delivery. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s11689-021-09377-y.
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spelling pubmed-83779672021-08-23 Neurodevelopmental profiles of preschool-age children in Flint, Michigan: a latent profile analysis Zheng, Shuting Bishop, Somer L. Ceja, Tiffany Hanna-Attisha, Mona LeWinn, Kaja J Neurodev Disord Research OBJECTIVE: Children in Flint, Michigan, have experienced myriad sociodemographic adversities exacerbated by the Flint water crisis. To help inform child-focused prevention and intervention efforts, we aimed to describe patterns of neurodevelopmental outcomes among preschoolers who experienced the Flint water crisis before age 2 years. METHOD: Participants were 170 preschoolers who completed a comprehensive neurodevelopmental assessment battery, including directly administered measures of cognitive and executive functioning and maternal-report of adaptive skills and behavioral problems. We used latent profile analysis to derive subgroups. Multivariate multinomial logistic regression was conducted to examine the predictors of profile memberships, including child sex and maternal/family-level factors selected from an array of measured exposures using least absolute shrinkage and selection operator regression. RESULTS: Three latent profiles were identified: Profile 1—relative weakness in all domains (50%); Profile 2—normative functioning in all domains (34.1%); and Profile 3—relative strengths in executive function and behavior (15.9%). Profile 1 showed lower scores across cognitive and behavioral domains. Profile 2 demonstrated abilities within the normal range across domains. Profile 3 showed relative strength in executive functioning with few behavior problems, despite lower cognitive performance. Children across all profiles showed adaptive behavior in the adequate range. Child sex and maternal IQ were significant predictors of profile membership. CONCLUSIONS: Children in Flint demonstrated diverse patterns of development in the face of sociodemographic and environmental adversities. Comprehensive screening and neurodevelopmental profiling of children in this at-risk population are needed to identify areas of needs and inform appropriate service delivery. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s11689-021-09377-y. BioMed Central 2021-08-19 /pmc/articles/PMC8377967/ /pubmed/34412591 http://dx.doi.org/10.1186/s11689-021-09377-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Zheng, Shuting
Bishop, Somer L.
Ceja, Tiffany
Hanna-Attisha, Mona
LeWinn, Kaja
Neurodevelopmental profiles of preschool-age children in Flint, Michigan: a latent profile analysis
title Neurodevelopmental profiles of preschool-age children in Flint, Michigan: a latent profile analysis
title_full Neurodevelopmental profiles of preschool-age children in Flint, Michigan: a latent profile analysis
title_fullStr Neurodevelopmental profiles of preschool-age children in Flint, Michigan: a latent profile analysis
title_full_unstemmed Neurodevelopmental profiles of preschool-age children in Flint, Michigan: a latent profile analysis
title_short Neurodevelopmental profiles of preschool-age children in Flint, Michigan: a latent profile analysis
title_sort neurodevelopmental profiles of preschool-age children in flint, michigan: a latent profile analysis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377967/
https://www.ncbi.nlm.nih.gov/pubmed/34412591
http://dx.doi.org/10.1186/s11689-021-09377-y
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