Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopathy reveals discrete expression profiles associated with neurodegenerative progression and recovery

The microglial reaction is a hallmark of neurodegenerative conditions, and elements thereof may exert differential effects on disease progression, either worsening or ameliorating severity. In amyotrophic lateral sclerosis (ALS), a syndrome characterized by cytoplasmic aggregation of TDP-43 protein...

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Detalles Bibliográficos
Autores principales: Hunter, Mandana, Spiller, Krista J., Dominique, Myrna A., Xu, Hong, Hunter, Francis W., Fang, Terry C., Canter, Rebecca G., Roberts, Christopher J., Ransohoff, Richard M., Trojanowski, John Q., Lee, Virginia M.-Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377972/
https://www.ncbi.nlm.nih.gov/pubmed/34412701
http://dx.doi.org/10.1186/s40478-021-01239-x

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