Carriage of colistin-resistant Gram-negative bacteria in children from communities in Cape Town (Tuberculosis child multidrug-resistant preventive therapy trial sub-study)

Colistin is a last-resort antibiotic against multidrug-resistant, Gram-negative bacteria. Colistin resistance has been described in the clinical settings in South Africa. However, information on carriage of these bacteria in communities is limited. This study investigated gastrointestinal carriage o...

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Autores principales: Snyman, Yolandi, Whitelaw, Andrew C., Maloba, Motlatji R.B., Hesseling, Anneke C., Newton-Foot, Mae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AOSIS 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378148/
https://www.ncbi.nlm.nih.gov/pubmed/34485500
http://dx.doi.org/10.4102/sajid.v36i1.241
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author Snyman, Yolandi
Whitelaw, Andrew C.
Maloba, Motlatji R.B.
Hesseling, Anneke C.
Newton-Foot, Mae
author_facet Snyman, Yolandi
Whitelaw, Andrew C.
Maloba, Motlatji R.B.
Hesseling, Anneke C.
Newton-Foot, Mae
author_sort Snyman, Yolandi
collection PubMed
description Colistin is a last-resort antibiotic against multidrug-resistant, Gram-negative bacteria. Colistin resistance has been described in the clinical settings in South Africa. However, information on carriage of these bacteria in communities is limited. This study investigated gastrointestinal carriage of colistin-resistant Escherichia coli and Klebsiella spp. and mcr genes in children from communities in Cape Town. Colistin-resistant E. coli was isolated from two participants (4%, 2/50), and mcr-1-mcr-9 genes were not detected. Gastrointestinal carriage of colistin-resistant Enterobacterales was rare; however, continuous extensive surveillance is necessary to determine the extent of carriage and its contribution to resistance observed in clinical settings.
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spelling pubmed-83781482021-09-03 Carriage of colistin-resistant Gram-negative bacteria in children from communities in Cape Town (Tuberculosis child multidrug-resistant preventive therapy trial sub-study) Snyman, Yolandi Whitelaw, Andrew C. Maloba, Motlatji R.B. Hesseling, Anneke C. Newton-Foot, Mae S Afr J Infect Dis Brief Report Colistin is a last-resort antibiotic against multidrug-resistant, Gram-negative bacteria. Colistin resistance has been described in the clinical settings in South Africa. However, information on carriage of these bacteria in communities is limited. This study investigated gastrointestinal carriage of colistin-resistant Escherichia coli and Klebsiella spp. and mcr genes in children from communities in Cape Town. Colistin-resistant E. coli was isolated from two participants (4%, 2/50), and mcr-1-mcr-9 genes were not detected. Gastrointestinal carriage of colistin-resistant Enterobacterales was rare; however, continuous extensive surveillance is necessary to determine the extent of carriage and its contribution to resistance observed in clinical settings. AOSIS 2021-02-23 /pmc/articles/PMC8378148/ /pubmed/34485500 http://dx.doi.org/10.4102/sajid.v36i1.241 Text en © 2021. The Authors https://creativecommons.org/licenses/by/4.0/Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License.
spellingShingle Brief Report
Snyman, Yolandi
Whitelaw, Andrew C.
Maloba, Motlatji R.B.
Hesseling, Anneke C.
Newton-Foot, Mae
Carriage of colistin-resistant Gram-negative bacteria in children from communities in Cape Town (Tuberculosis child multidrug-resistant preventive therapy trial sub-study)
title Carriage of colistin-resistant Gram-negative bacteria in children from communities in Cape Town (Tuberculosis child multidrug-resistant preventive therapy trial sub-study)
title_full Carriage of colistin-resistant Gram-negative bacteria in children from communities in Cape Town (Tuberculosis child multidrug-resistant preventive therapy trial sub-study)
title_fullStr Carriage of colistin-resistant Gram-negative bacteria in children from communities in Cape Town (Tuberculosis child multidrug-resistant preventive therapy trial sub-study)
title_full_unstemmed Carriage of colistin-resistant Gram-negative bacteria in children from communities in Cape Town (Tuberculosis child multidrug-resistant preventive therapy trial sub-study)
title_short Carriage of colistin-resistant Gram-negative bacteria in children from communities in Cape Town (Tuberculosis child multidrug-resistant preventive therapy trial sub-study)
title_sort carriage of colistin-resistant gram-negative bacteria in children from communities in cape town (tuberculosis child multidrug-resistant preventive therapy trial sub-study)
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378148/
https://www.ncbi.nlm.nih.gov/pubmed/34485500
http://dx.doi.org/10.4102/sajid.v36i1.241
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