Cargando…
Regenerative Medicine Technologies to Treat Dental, Oral, and Craniofacial Defects
Additive manufacturing (AM) is the automated production of three-dimensional (3D) structures through successive layer-by-layer deposition of materials directed by computer-aided-design (CAD) software. While current clinical procedures that aim to reconstruct hard and soft tissue defects resulting fr...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378232/ https://www.ncbi.nlm.nih.gov/pubmed/34422781 http://dx.doi.org/10.3389/fbioe.2021.704048 |
_version_ | 1783740799097241600 |
---|---|
author | Latimer, Jessica M. Maekawa, Shogo Yao, Yao Wu, David T. Chen, Michael Giannobile, William V. |
author_facet | Latimer, Jessica M. Maekawa, Shogo Yao, Yao Wu, David T. Chen, Michael Giannobile, William V. |
author_sort | Latimer, Jessica M. |
collection | PubMed |
description | Additive manufacturing (AM) is the automated production of three-dimensional (3D) structures through successive layer-by-layer deposition of materials directed by computer-aided-design (CAD) software. While current clinical procedures that aim to reconstruct hard and soft tissue defects resulting from periodontal disease, congenital or acquired pathology, and maxillofacial trauma often utilize mass-produced biomaterials created for a variety of surgical indications, AM represents a paradigm shift in manufacturing at the individual patient level. Computer-aided systems employ algorithms to design customized, image-based scaffolds with high external shape complexity and spatial patterning of internal architecture guided by topology optimization. 3D bioprinting and surface modification techniques further enhance scaffold functionalization and osteogenic potential through the incorporation of viable cells, bioactive molecules, biomimetic materials and vectors for transgene expression within the layered architecture. These computational design features enable fabrication of tissue engineering constructs with highly tailored mechanical, structural, and biochemical properties for bone. This review examines key properties of scaffold design, bioresorbable bone scaffolds produced by AM processes, and clinical applications of these regenerative technologies. AM is transforming the field of personalized dental medicine and has great potential to improve regenerative outcomes in patient care. |
format | Online Article Text |
id | pubmed-8378232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83782322021-08-21 Regenerative Medicine Technologies to Treat Dental, Oral, and Craniofacial Defects Latimer, Jessica M. Maekawa, Shogo Yao, Yao Wu, David T. Chen, Michael Giannobile, William V. Front Bioeng Biotechnol Bioengineering and Biotechnology Additive manufacturing (AM) is the automated production of three-dimensional (3D) structures through successive layer-by-layer deposition of materials directed by computer-aided-design (CAD) software. While current clinical procedures that aim to reconstruct hard and soft tissue defects resulting from periodontal disease, congenital or acquired pathology, and maxillofacial trauma often utilize mass-produced biomaterials created for a variety of surgical indications, AM represents a paradigm shift in manufacturing at the individual patient level. Computer-aided systems employ algorithms to design customized, image-based scaffolds with high external shape complexity and spatial patterning of internal architecture guided by topology optimization. 3D bioprinting and surface modification techniques further enhance scaffold functionalization and osteogenic potential through the incorporation of viable cells, bioactive molecules, biomimetic materials and vectors for transgene expression within the layered architecture. These computational design features enable fabrication of tissue engineering constructs with highly tailored mechanical, structural, and biochemical properties for bone. This review examines key properties of scaffold design, bioresorbable bone scaffolds produced by AM processes, and clinical applications of these regenerative technologies. AM is transforming the field of personalized dental medicine and has great potential to improve regenerative outcomes in patient care. Frontiers Media S.A. 2021-08-06 /pmc/articles/PMC8378232/ /pubmed/34422781 http://dx.doi.org/10.3389/fbioe.2021.704048 Text en Copyright © 2021 Latimer, Maekawa, Yao, Wu, Chen and Giannobile. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Latimer, Jessica M. Maekawa, Shogo Yao, Yao Wu, David T. Chen, Michael Giannobile, William V. Regenerative Medicine Technologies to Treat Dental, Oral, and Craniofacial Defects |
title | Regenerative Medicine Technologies to Treat Dental, Oral, and Craniofacial Defects |
title_full | Regenerative Medicine Technologies to Treat Dental, Oral, and Craniofacial Defects |
title_fullStr | Regenerative Medicine Technologies to Treat Dental, Oral, and Craniofacial Defects |
title_full_unstemmed | Regenerative Medicine Technologies to Treat Dental, Oral, and Craniofacial Defects |
title_short | Regenerative Medicine Technologies to Treat Dental, Oral, and Craniofacial Defects |
title_sort | regenerative medicine technologies to treat dental, oral, and craniofacial defects |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378232/ https://www.ncbi.nlm.nih.gov/pubmed/34422781 http://dx.doi.org/10.3389/fbioe.2021.704048 |
work_keys_str_mv | AT latimerjessicam regenerativemedicinetechnologiestotreatdentaloralandcraniofacialdefects AT maekawashogo regenerativemedicinetechnologiestotreatdentaloralandcraniofacialdefects AT yaoyao regenerativemedicinetechnologiestotreatdentaloralandcraniofacialdefects AT wudavidt regenerativemedicinetechnologiestotreatdentaloralandcraniofacialdefects AT chenmichael regenerativemedicinetechnologiestotreatdentaloralandcraniofacialdefects AT giannobilewilliamv regenerativemedicinetechnologiestotreatdentaloralandcraniofacialdefects |