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Comparison of Two Dosages of Ketamine in Preventing Fentanyl-Induced Coughs in Children

BACKGROUND: Fentanyl is a short-acting drug used to induce anesthesia. Here, we aimed to compare the two doses of ketamine to prevent fentanyl-induced cough in children under general anesthesia. MATERIALS AND METHODS: This is a randomized, clinical trial which was performed in 2019 in Imam Hossein H...

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Detalles Bibliográficos
Autores principales: Shafa, Amir, Shahhosseini, Sedighe, Rajaee, Elham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378446/
https://www.ncbi.nlm.nih.gov/pubmed/34476228
http://dx.doi.org/10.4103/abr.abr_218_20
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author Shafa, Amir
Shahhosseini, Sedighe
Rajaee, Elham
author_facet Shafa, Amir
Shahhosseini, Sedighe
Rajaee, Elham
author_sort Shafa, Amir
collection PubMed
description BACKGROUND: Fentanyl is a short-acting drug used to induce anesthesia. Here, we aimed to compare the two doses of ketamine to prevent fentanyl-induced cough in children under general anesthesia. MATERIALS AND METHODS: This is a randomized, clinical trial which was performed in 2019 in Imam Hossein Hospital in Isfahan, Iran. The study population consisted of children between 6 months and 2 years who were candidates for general anesthesia. Patients were randomized into three groups, each containing 31 patients. Groups 1 and 2 received 0.1 mg/kg and 0.2 mg/kg intravenous ketamine, respectively, 1 min before fentanyl injections. Group 3 received the same volumes of normal saline 0.9%. Patients were observed and evaluated for the incidence and intensity of coughs 1 min and 3 min after fentanyl injections. RESULTS: We showed that the frequency of coughs 1 min after fentanyl injection was significantly lower in Group 2 compared to other groups (P < 0.001). Three min after fentanyl injection, the frequencies of coughs were significantly lower in Groups 1 and 2 compared to Group 3 (P < 0.001). We also showed that the intensity of coughs was significantly lower in Group 2 compared to other Groups 1 and 3 min after fentanyl injection (P < 0.001). CONCLUSION: The administration of 0.2 mg/kg ketamine is more effective than 0.1 mg/kg dosage in the prevention of fentanyl-induced cough. We also showed that this method could bring more stable hemodynamics and oxygenation saturation inpatients. The comparison of the two dosages was a novel issue in the recent literature.
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spelling pubmed-83784462021-09-01 Comparison of Two Dosages of Ketamine in Preventing Fentanyl-Induced Coughs in Children Shafa, Amir Shahhosseini, Sedighe Rajaee, Elham Adv Biomed Res Original Article BACKGROUND: Fentanyl is a short-acting drug used to induce anesthesia. Here, we aimed to compare the two doses of ketamine to prevent fentanyl-induced cough in children under general anesthesia. MATERIALS AND METHODS: This is a randomized, clinical trial which was performed in 2019 in Imam Hossein Hospital in Isfahan, Iran. The study population consisted of children between 6 months and 2 years who were candidates for general anesthesia. Patients were randomized into three groups, each containing 31 patients. Groups 1 and 2 received 0.1 mg/kg and 0.2 mg/kg intravenous ketamine, respectively, 1 min before fentanyl injections. Group 3 received the same volumes of normal saline 0.9%. Patients were observed and evaluated for the incidence and intensity of coughs 1 min and 3 min after fentanyl injections. RESULTS: We showed that the frequency of coughs 1 min after fentanyl injection was significantly lower in Group 2 compared to other groups (P < 0.001). Three min after fentanyl injection, the frequencies of coughs were significantly lower in Groups 1 and 2 compared to Group 3 (P < 0.001). We also showed that the intensity of coughs was significantly lower in Group 2 compared to other Groups 1 and 3 min after fentanyl injection (P < 0.001). CONCLUSION: The administration of 0.2 mg/kg ketamine is more effective than 0.1 mg/kg dosage in the prevention of fentanyl-induced cough. We also showed that this method could bring more stable hemodynamics and oxygenation saturation inpatients. The comparison of the two dosages was a novel issue in the recent literature. Wolters Kluwer - Medknow 2021-07-29 /pmc/articles/PMC8378446/ /pubmed/34476228 http://dx.doi.org/10.4103/abr.abr_218_20 Text en Copyright: © 2021 Advanced Biomedical Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Shafa, Amir
Shahhosseini, Sedighe
Rajaee, Elham
Comparison of Two Dosages of Ketamine in Preventing Fentanyl-Induced Coughs in Children
title Comparison of Two Dosages of Ketamine in Preventing Fentanyl-Induced Coughs in Children
title_full Comparison of Two Dosages of Ketamine in Preventing Fentanyl-Induced Coughs in Children
title_fullStr Comparison of Two Dosages of Ketamine in Preventing Fentanyl-Induced Coughs in Children
title_full_unstemmed Comparison of Two Dosages of Ketamine in Preventing Fentanyl-Induced Coughs in Children
title_short Comparison of Two Dosages of Ketamine in Preventing Fentanyl-Induced Coughs in Children
title_sort comparison of two dosages of ketamine in preventing fentanyl-induced coughs in children
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378446/
https://www.ncbi.nlm.nih.gov/pubmed/34476228
http://dx.doi.org/10.4103/abr.abr_218_20
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