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Diabetes and Heart Failure: Multi-Omics Approaches

Diabetes and heart failure, as important global issues, cause substantial expenses to countries and medical systems because of the morbidity and mortality rates. Most people with diabetes suffer from type 2 diabetes, which has an amplifying effect on the prevalence and severity of many health proble...

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Autores principales: Tayanloo-Beik, Akram, Roudsari, Peyvand Parhizkar, Rezaei-Tavirani, Mostafa, Biglar, Mahmood, Tabatabaei-Malazy, Ozra, Arjmand, Babak, Larijani, Bagher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378451/
https://www.ncbi.nlm.nih.gov/pubmed/34421642
http://dx.doi.org/10.3389/fphys.2021.705424
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author Tayanloo-Beik, Akram
Roudsari, Peyvand Parhizkar
Rezaei-Tavirani, Mostafa
Biglar, Mahmood
Tabatabaei-Malazy, Ozra
Arjmand, Babak
Larijani, Bagher
author_facet Tayanloo-Beik, Akram
Roudsari, Peyvand Parhizkar
Rezaei-Tavirani, Mostafa
Biglar, Mahmood
Tabatabaei-Malazy, Ozra
Arjmand, Babak
Larijani, Bagher
author_sort Tayanloo-Beik, Akram
collection PubMed
description Diabetes and heart failure, as important global issues, cause substantial expenses to countries and medical systems because of the morbidity and mortality rates. Most people with diabetes suffer from type 2 diabetes, which has an amplifying effect on the prevalence and severity of many health problems such as stroke, neuropathy, retinopathy, kidney injuries, and cardiovascular disease. Type 2 diabetes is one of the cornerstones of heart failure, another health epidemic, with 44% prevalence. Therefore, finding and targeting specific molecular and cellular pathways involved in the pathophysiology of each disease, either in diagnosis or treatment, will be beneficial. For diabetic cardiomyopathy, there are several mechanisms through which clinical heart failure is developed; oxidative stress with mediation of reactive oxygen species (ROS), reduced myocardial perfusion due to endothelial dysfunction, autonomic dysfunction, and metabolic changes, such as impaired glucose levels caused by insulin resistance, are the four main mechanisms. In the field of oxidative stress, advanced glycation end products (AGEs), protein kinase C (PKC), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) are the key mediators that new omics-driven methods can target. Besides, diabetes can affect myocardial function by impairing calcium (Ca) homeostasis, the mechanism in which reduced protein phosphatase 1 (PP1), sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2a (SERCA2a), and phosphorylated SERCA2a expressions are the main effectors. This article reviewed the recent omics-driven discoveries in the diagnosis and treatment of type 2 diabetes and heart failure with focus on the common molecular mechanisms.
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spelling pubmed-83784512021-08-21 Diabetes and Heart Failure: Multi-Omics Approaches Tayanloo-Beik, Akram Roudsari, Peyvand Parhizkar Rezaei-Tavirani, Mostafa Biglar, Mahmood Tabatabaei-Malazy, Ozra Arjmand, Babak Larijani, Bagher Front Physiol Physiology Diabetes and heart failure, as important global issues, cause substantial expenses to countries and medical systems because of the morbidity and mortality rates. Most people with diabetes suffer from type 2 diabetes, which has an amplifying effect on the prevalence and severity of many health problems such as stroke, neuropathy, retinopathy, kidney injuries, and cardiovascular disease. Type 2 diabetes is one of the cornerstones of heart failure, another health epidemic, with 44% prevalence. Therefore, finding and targeting specific molecular and cellular pathways involved in the pathophysiology of each disease, either in diagnosis or treatment, will be beneficial. For diabetic cardiomyopathy, there are several mechanisms through which clinical heart failure is developed; oxidative stress with mediation of reactive oxygen species (ROS), reduced myocardial perfusion due to endothelial dysfunction, autonomic dysfunction, and metabolic changes, such as impaired glucose levels caused by insulin resistance, are the four main mechanisms. In the field of oxidative stress, advanced glycation end products (AGEs), protein kinase C (PKC), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) are the key mediators that new omics-driven methods can target. Besides, diabetes can affect myocardial function by impairing calcium (Ca) homeostasis, the mechanism in which reduced protein phosphatase 1 (PP1), sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2a (SERCA2a), and phosphorylated SERCA2a expressions are the main effectors. This article reviewed the recent omics-driven discoveries in the diagnosis and treatment of type 2 diabetes and heart failure with focus on the common molecular mechanisms. Frontiers Media S.A. 2021-08-06 /pmc/articles/PMC8378451/ /pubmed/34421642 http://dx.doi.org/10.3389/fphys.2021.705424 Text en Copyright © 2021 Tayanloo-Beik, Roudsari, Rezaei-Tavirani, Biglar, Tabatabaei-Malazy, Arjmand and Larijani. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Tayanloo-Beik, Akram
Roudsari, Peyvand Parhizkar
Rezaei-Tavirani, Mostafa
Biglar, Mahmood
Tabatabaei-Malazy, Ozra
Arjmand, Babak
Larijani, Bagher
Diabetes and Heart Failure: Multi-Omics Approaches
title Diabetes and Heart Failure: Multi-Omics Approaches
title_full Diabetes and Heart Failure: Multi-Omics Approaches
title_fullStr Diabetes and Heart Failure: Multi-Omics Approaches
title_full_unstemmed Diabetes and Heart Failure: Multi-Omics Approaches
title_short Diabetes and Heart Failure: Multi-Omics Approaches
title_sort diabetes and heart failure: multi-omics approaches
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378451/
https://www.ncbi.nlm.nih.gov/pubmed/34421642
http://dx.doi.org/10.3389/fphys.2021.705424
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