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Blood Prestin Levels in Normal Hearing and in Sensorineural Hearing Loss: A Scoping Review

OBJECTIVES: Recently, it has been hypothesized that blood prestin concentration levels may reflect cochlear damage and thus serve as an easily measurable, early sensorineural hearing loss (HL) biomarker. This is a scoping review aiming to identify and critically appraise current evidence on prestin...

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Autores principales: Iliadou, Eleftheria, Kikidis, Dimitrios, Pastiadis, Konstantinos, Plack, Christopher J., Bibas, Athanasios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378539/
https://www.ncbi.nlm.nih.gov/pubmed/33900207
http://dx.doi.org/10.1097/AUD.0000000000001045
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author Iliadou, Eleftheria
Kikidis, Dimitrios
Pastiadis, Konstantinos
Plack, Christopher J.
Bibas, Athanasios
author_facet Iliadou, Eleftheria
Kikidis, Dimitrios
Pastiadis, Konstantinos
Plack, Christopher J.
Bibas, Athanasios
author_sort Iliadou, Eleftheria
collection PubMed
description OBJECTIVES: Recently, it has been hypothesized that blood prestin concentration levels may reflect cochlear damage and thus serve as an easily measurable, early sensorineural hearing loss (HL) biomarker. This is a scoping review aiming to identify and critically appraise current evidence on prestin blood levels and their temporal variation in rodents and humans with normal hearing and with sensorineural HL. DESIGN: This study was designed and held according to PRISMA Extension for Scoping Reviews (PRISMA-ScR) guidelines. With no limitation with regards to study type, animal and human studies focusing on prestin blood levels in normal hearing and in sensorineural HL were sought in major databases such as Medline, Central Scopus, PROSPERO, and Clinicaltrials.gov. Results were then hand-searched. A data charting form was developed including the parameters of interest. RESULTS: Seven studies focusing on measuring prestin blood levels by means of ELISA in rodents and human subjects with normal hearing and noise-induced, drug-induced, or idiopathic sudden HL were found eligible and were included in the analysis. According to these proof-of-concept studies, prestin can be detected in the circulation of subjects with no HL; however, normal ranges remain unclear. After cochlear damage, blood prestin levels seem to initially rise and then return to near or below baseline. The degree of their change relates with subjects’ degree of HL, damaged cochlear region and recovery. Prestin blood levels and their temporal variation seem to correlate with cochlear damage; however, methodological weaknesses, such as small sample size, lack of detailed phenotyping, insufficient exclusion of confounding factors, and short follow-up, do not allow for robust conclusions. CONCLUSIONS: Current findings support the value of studying blood prestin levels in normal hearing and HL and highlight a need for larger-scale longitudinal research.
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spelling pubmed-83785392021-09-01 Blood Prestin Levels in Normal Hearing and in Sensorineural Hearing Loss: A Scoping Review Iliadou, Eleftheria Kikidis, Dimitrios Pastiadis, Konstantinos Plack, Christopher J. Bibas, Athanasios Ear Hear Scoping Review OBJECTIVES: Recently, it has been hypothesized that blood prestin concentration levels may reflect cochlear damage and thus serve as an easily measurable, early sensorineural hearing loss (HL) biomarker. This is a scoping review aiming to identify and critically appraise current evidence on prestin blood levels and their temporal variation in rodents and humans with normal hearing and with sensorineural HL. DESIGN: This study was designed and held according to PRISMA Extension for Scoping Reviews (PRISMA-ScR) guidelines. With no limitation with regards to study type, animal and human studies focusing on prestin blood levels in normal hearing and in sensorineural HL were sought in major databases such as Medline, Central Scopus, PROSPERO, and Clinicaltrials.gov. Results were then hand-searched. A data charting form was developed including the parameters of interest. RESULTS: Seven studies focusing on measuring prestin blood levels by means of ELISA in rodents and human subjects with normal hearing and noise-induced, drug-induced, or idiopathic sudden HL were found eligible and were included in the analysis. According to these proof-of-concept studies, prestin can be detected in the circulation of subjects with no HL; however, normal ranges remain unclear. After cochlear damage, blood prestin levels seem to initially rise and then return to near or below baseline. The degree of their change relates with subjects’ degree of HL, damaged cochlear region and recovery. Prestin blood levels and their temporal variation seem to correlate with cochlear damage; however, methodological weaknesses, such as small sample size, lack of detailed phenotyping, insufficient exclusion of confounding factors, and short follow-up, do not allow for robust conclusions. CONCLUSIONS: Current findings support the value of studying blood prestin levels in normal hearing and HL and highlight a need for larger-scale longitudinal research. Lippincott Williams & Wilkins 2021-04-22 /pmc/articles/PMC8378539/ /pubmed/33900207 http://dx.doi.org/10.1097/AUD.0000000000001045 Text en Copyright © 2021 The Authors. Ear & Hearing is published on behalf of the American Auditory Society, by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Scoping Review
Iliadou, Eleftheria
Kikidis, Dimitrios
Pastiadis, Konstantinos
Plack, Christopher J.
Bibas, Athanasios
Blood Prestin Levels in Normal Hearing and in Sensorineural Hearing Loss: A Scoping Review
title Blood Prestin Levels in Normal Hearing and in Sensorineural Hearing Loss: A Scoping Review
title_full Blood Prestin Levels in Normal Hearing and in Sensorineural Hearing Loss: A Scoping Review
title_fullStr Blood Prestin Levels in Normal Hearing and in Sensorineural Hearing Loss: A Scoping Review
title_full_unstemmed Blood Prestin Levels in Normal Hearing and in Sensorineural Hearing Loss: A Scoping Review
title_short Blood Prestin Levels in Normal Hearing and in Sensorineural Hearing Loss: A Scoping Review
title_sort blood prestin levels in normal hearing and in sensorineural hearing loss: a scoping review
topic Scoping Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378539/
https://www.ncbi.nlm.nih.gov/pubmed/33900207
http://dx.doi.org/10.1097/AUD.0000000000001045
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