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Hypofractionation: less is more?

One third of patients with bladder cancer present with muscle invasive bladder cancer (MIBC) which has a poor prognosis. International guidelines for the management of MIBC recommend radical cystectomy or bladder-preserving treatment based on radical radiotherapy with a form of radiosensitisation. I...

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Autores principales: Mariam, Neethu Billy Graham, Song, Yee Pei, Joseph, Nuradh, Hoskin, Peter, Reeves, Kimberley, Porta, Nuria, James, Nicholas, Choudhury, Ananya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378765/
https://www.ncbi.nlm.nih.gov/pubmed/34434502
http://dx.doi.org/10.18632/oncotarget.28023
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author Mariam, Neethu Billy Graham
Song, Yee Pei
Joseph, Nuradh
Hoskin, Peter
Reeves, Kimberley
Porta, Nuria
James, Nicholas
Choudhury, Ananya
author_facet Mariam, Neethu Billy Graham
Song, Yee Pei
Joseph, Nuradh
Hoskin, Peter
Reeves, Kimberley
Porta, Nuria
James, Nicholas
Choudhury, Ananya
author_sort Mariam, Neethu Billy Graham
collection PubMed
description One third of patients with bladder cancer present with muscle invasive bladder cancer (MIBC) which has a poor prognosis. International guidelines for the management of MIBC recommend radical cystectomy or bladder-preserving treatment based on radical radiotherapy with a form of radiosensitisation. In the UK, both conventional fractionation with 64 Gy in 32 fractions and hypofractionation with 55 Gy in 20 fractions are standard of care options with the choice varying between centres. A meta-analysis of individual patients with locally advanced bladder cancer from two UK multicentre phase 3 trials was published recently. This study evaluated the non-inferiority of a hypofractionated schedule compared to a conventional regime. This analysis confirmed the non-inferiority of the hypofractionated regimen, and noted superior locoregional control. We discuss the relevance of these findings to current practice while considering the radiobiology of hypofractionation, the role of systemic therapies and radiosensitisation, as well as the socioeconomic benefits.
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spelling pubmed-83787652021-08-24 Hypofractionation: less is more? Mariam, Neethu Billy Graham Song, Yee Pei Joseph, Nuradh Hoskin, Peter Reeves, Kimberley Porta, Nuria James, Nicholas Choudhury, Ananya Oncotarget Research Perspective One third of patients with bladder cancer present with muscle invasive bladder cancer (MIBC) which has a poor prognosis. International guidelines for the management of MIBC recommend radical cystectomy or bladder-preserving treatment based on radical radiotherapy with a form of radiosensitisation. In the UK, both conventional fractionation with 64 Gy in 32 fractions and hypofractionation with 55 Gy in 20 fractions are standard of care options with the choice varying between centres. A meta-analysis of individual patients with locally advanced bladder cancer from two UK multicentre phase 3 trials was published recently. This study evaluated the non-inferiority of a hypofractionated schedule compared to a conventional regime. This analysis confirmed the non-inferiority of the hypofractionated regimen, and noted superior locoregional control. We discuss the relevance of these findings to current practice while considering the radiobiology of hypofractionation, the role of systemic therapies and radiosensitisation, as well as the socioeconomic benefits. Impact Journals LLC 2021-08-17 /pmc/articles/PMC8378765/ /pubmed/34434502 http://dx.doi.org/10.18632/oncotarget.28023 Text en Copyright: © 2021 Mariam et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Perspective
Mariam, Neethu Billy Graham
Song, Yee Pei
Joseph, Nuradh
Hoskin, Peter
Reeves, Kimberley
Porta, Nuria
James, Nicholas
Choudhury, Ananya
Hypofractionation: less is more?
title Hypofractionation: less is more?
title_full Hypofractionation: less is more?
title_fullStr Hypofractionation: less is more?
title_full_unstemmed Hypofractionation: less is more?
title_short Hypofractionation: less is more?
title_sort hypofractionation: less is more?
topic Research Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378765/
https://www.ncbi.nlm.nih.gov/pubmed/34434502
http://dx.doi.org/10.18632/oncotarget.28023
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