X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis

Isopenicillin N synthase (IPNS) catalyzes the unique reaction of l-δ-(α-aminoadipoyl)-l-cysteinyl-d-valine (ACV) with dioxygen giving isopenicillin N (IPN), the precursor of all natural penicillins and cephalosporins. X-ray free-electron laser studies including time-resolved crystallography and emis...

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Detalles Bibliográficos
Autores principales: Rabe, Patrick, Kamps, Jos J. A. G., Sutherlin, Kyle D., Linyard, James D. S., Aller, Pierre, Pham, Cindy C., Makita, Hiroki, Clifton, Ian, McDonough, Michael A., Leissing, Thomas M., Shutin, Denis, Lang, Pauline A., Butryn, Agata, Brem, Jürgen, Gul, Sheraz, Fuller, Franklin D., Kim, In-Sik, Cheah, Mun Hon, Fransson, Thomas, Bhowmick, Asmit, Young, Iris D., O’Riordan, Lee, Brewster, Aaron S., Pettinati, Ilaria, Doyle, Margaret, Joti, Yasumasa, Owada, Shigeki, Tono, Kensuke, Batyuk, Alexander, Hunter, Mark S., Alonso-Mori, Roberto, Bergmann, Uwe, Owen, Robin L., Sauter, Nicholas K., Claridge, Timothy D. W., Robinson, Carol V., Yachandra, Vittal K., Yano, Junko, Kern, Jan F., Orville, Allen M., Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378823/
https://www.ncbi.nlm.nih.gov/pubmed/34417180
http://dx.doi.org/10.1126/sciadv.abh0250

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