Cargando…

Correlation between Imaging Morphological Findings and Laboratory Biomarkers in Patients with Diabetic Macular Edema

PURPOSE: To investigate the potential association between peripheral blood biomarkers and morphological characteristics of retinal imaging in patients with diabetic macular edema (DME). METHODS: Participants in this cross-sectional study were 36 consecutive patients (36 eyes) with treatment-naïve DM...

Descripción completa

Detalles Bibliográficos
Autores principales: Dimitriou, Eleni, Sergentanis, Theodoros N., Lambadiari, Vaia, Theodossiadis, George, Theodossiadis, Panagiotis, Chatziralli, Irini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378977/
https://www.ncbi.nlm.nih.gov/pubmed/34423046
http://dx.doi.org/10.1155/2021/6426003
_version_ 1783740913647878144
author Dimitriou, Eleni
Sergentanis, Theodoros N.
Lambadiari, Vaia
Theodossiadis, George
Theodossiadis, Panagiotis
Chatziralli, Irini
author_facet Dimitriou, Eleni
Sergentanis, Theodoros N.
Lambadiari, Vaia
Theodossiadis, George
Theodossiadis, Panagiotis
Chatziralli, Irini
author_sort Dimitriou, Eleni
collection PubMed
description PURPOSE: To investigate the potential association between peripheral blood biomarkers and morphological characteristics of retinal imaging in patients with diabetic macular edema (DME). METHODS: Participants in this cross-sectional study were 36 consecutive patients (36 eyes) with treatment-naïve DME, who underwent spectral domain-optical coherence tomography (SD-OCT), fundus photography, and fundus fluorescein angiography (FFA). In addition, peripheral blood samples were taken to evaluate full blood count and biochemical parameters. Correlation between imaging characteristics and laboratory parameters was examined. RESULTS: Eyes with central subfield thickness greater than 405 μm presented significantly higher neutrophils/lymphocytes (p = 0.043) and higher lipoprotein (a) compared to eyes with CST < 405 μm (p = 0.003). Presence of hyperreflective foci on SD-OCT was associated with significantly higher white blood cell count (p = 0.028). Ellipsoid zone disruption was associated with significantly lower hematocrit (p = 0.012), hemoglobin (p = 0.009), and red blood cell count (p = 0.026), as well as with higher lipoprotein (a) (p = 0.015). Macular ischemia on FFA was associated with significantly higher monocytes (p = 0.027) and monocytes/HDL (p = 0.019). No significant associations were found between laboratory parameters and subretinal fluid, intraretinal fluid, exudates, cysts, disorganization of inner retinal layers, epiretinal membrane, and external limiting membrane condition. CONCLUSION: Specific imaging morphological characteristics were found to be associated with laboratory parameters in patients with DME. These findings may shed light on the pathophysiology of DME and its correlation with the development of specific clinical signs.
format Online
Article
Text
id pubmed-8378977
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-83789772021-08-21 Correlation between Imaging Morphological Findings and Laboratory Biomarkers in Patients with Diabetic Macular Edema Dimitriou, Eleni Sergentanis, Theodoros N. Lambadiari, Vaia Theodossiadis, George Theodossiadis, Panagiotis Chatziralli, Irini J Diabetes Res Research Article PURPOSE: To investigate the potential association between peripheral blood biomarkers and morphological characteristics of retinal imaging in patients with diabetic macular edema (DME). METHODS: Participants in this cross-sectional study were 36 consecutive patients (36 eyes) with treatment-naïve DME, who underwent spectral domain-optical coherence tomography (SD-OCT), fundus photography, and fundus fluorescein angiography (FFA). In addition, peripheral blood samples were taken to evaluate full blood count and biochemical parameters. Correlation between imaging characteristics and laboratory parameters was examined. RESULTS: Eyes with central subfield thickness greater than 405 μm presented significantly higher neutrophils/lymphocytes (p = 0.043) and higher lipoprotein (a) compared to eyes with CST < 405 μm (p = 0.003). Presence of hyperreflective foci on SD-OCT was associated with significantly higher white blood cell count (p = 0.028). Ellipsoid zone disruption was associated with significantly lower hematocrit (p = 0.012), hemoglobin (p = 0.009), and red blood cell count (p = 0.026), as well as with higher lipoprotein (a) (p = 0.015). Macular ischemia on FFA was associated with significantly higher monocytes (p = 0.027) and monocytes/HDL (p = 0.019). No significant associations were found between laboratory parameters and subretinal fluid, intraretinal fluid, exudates, cysts, disorganization of inner retinal layers, epiretinal membrane, and external limiting membrane condition. CONCLUSION: Specific imaging morphological characteristics were found to be associated with laboratory parameters in patients with DME. These findings may shed light on the pathophysiology of DME and its correlation with the development of specific clinical signs. Hindawi 2021-08-13 /pmc/articles/PMC8378977/ /pubmed/34423046 http://dx.doi.org/10.1155/2021/6426003 Text en Copyright © 2021 Eleni Dimitriou et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Dimitriou, Eleni
Sergentanis, Theodoros N.
Lambadiari, Vaia
Theodossiadis, George
Theodossiadis, Panagiotis
Chatziralli, Irini
Correlation between Imaging Morphological Findings and Laboratory Biomarkers in Patients with Diabetic Macular Edema
title Correlation between Imaging Morphological Findings and Laboratory Biomarkers in Patients with Diabetic Macular Edema
title_full Correlation between Imaging Morphological Findings and Laboratory Biomarkers in Patients with Diabetic Macular Edema
title_fullStr Correlation between Imaging Morphological Findings and Laboratory Biomarkers in Patients with Diabetic Macular Edema
title_full_unstemmed Correlation between Imaging Morphological Findings and Laboratory Biomarkers in Patients with Diabetic Macular Edema
title_short Correlation between Imaging Morphological Findings and Laboratory Biomarkers in Patients with Diabetic Macular Edema
title_sort correlation between imaging morphological findings and laboratory biomarkers in patients with diabetic macular edema
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378977/
https://www.ncbi.nlm.nih.gov/pubmed/34423046
http://dx.doi.org/10.1155/2021/6426003
work_keys_str_mv AT dimitrioueleni correlationbetweenimagingmorphologicalfindingsandlaboratorybiomarkersinpatientswithdiabeticmacularedema
AT sergentanistheodorosn correlationbetweenimagingmorphologicalfindingsandlaboratorybiomarkersinpatientswithdiabeticmacularedema
AT lambadiarivaia correlationbetweenimagingmorphologicalfindingsandlaboratorybiomarkersinpatientswithdiabeticmacularedema
AT theodossiadisgeorge correlationbetweenimagingmorphologicalfindingsandlaboratorybiomarkersinpatientswithdiabeticmacularedema
AT theodossiadispanagiotis correlationbetweenimagingmorphologicalfindingsandlaboratorybiomarkersinpatientswithdiabeticmacularedema
AT chatziralliirini correlationbetweenimagingmorphologicalfindingsandlaboratorybiomarkersinpatientswithdiabeticmacularedema