Elevated Expression of MiR-17 in Microglia of Alzheimer’s Disease Patients Abrogates Autophagy-Mediated Amyloid-β Degradation

Autophagy is a proposed route of amyloid-β (Aβ) clearance by microglia that is halted in Alzheimer’s Disease (AD), though mechanisms underlying this dysfunction remain elusive. Here, primary microglia from adult AD (5xFAD) mice were utilized to demonstrate that 5xFAD microglia fail to degrade Aβ and...

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Detalles Bibliográficos
Autores principales: Estfanous, Shady, Daily, Kylene P., Eltobgy, Mostafa, Deems, Nicholas P., Anne, Midhun N. K., Krause, Kathrin, Badr, Asmaa, Hamilton, Kaitlin, Carafice, Cierra, Hegazi, Ahmad, Abu Khweek, Arwa, Kelani, Hesham, Nimjee, Shahid, Awad, Hamdy, Zhang, Xiaoli, Cormet-Boyaka, Estelle, Haffez, Hesham, Soror, Sameh, Mikhail, Adel, Nuovo, Gerard, Barrientos, Ruth M., Gavrilin, Mikhail A., Amer, Amal O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379081/
https://www.ncbi.nlm.nih.gov/pubmed/34426734
http://dx.doi.org/10.3389/fimmu.2021.705581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379081/
https://www.ncbi.nlm.nih.gov/pubmed/34426734
http://dx.doi.org/10.3389/fimmu.2021.705581

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