Know your enemy and know yourself – the case of SARS-CoV-2 host factors

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiologic agent that causes Coronavirus Disease 2019 (COVID-19) pandemic, is a newly emerging respiratory RNA virus with exceptional transmissibility and pathogenicity. Numerous COVID-19 related studies have been fast-tracked, with th...

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Autores principales: Lee, Wai Suet, Yousefi, Meisam, Yan, Biaoguo, Yong, Cythia Lingli, Ooi, Yaw Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379091/
https://www.ncbi.nlm.nih.gov/pubmed/34488003
http://dx.doi.org/10.1016/j.coviro.2021.08.007
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author Lee, Wai Suet
Yousefi, Meisam
Yan, Biaoguo
Yong, Cythia Lingli
Ooi, Yaw Shin
author_facet Lee, Wai Suet
Yousefi, Meisam
Yan, Biaoguo
Yong, Cythia Lingli
Ooi, Yaw Shin
author_sort Lee, Wai Suet
collection PubMed
description Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiologic agent that causes Coronavirus Disease 2019 (COVID-19) pandemic, is a newly emerging respiratory RNA virus with exceptional transmissibility and pathogenicity. Numerous COVID-19 related studies have been fast-tracked, with the ultimate goal to end the pandemic. Here we review the major stages of SARS-CoV-2 infection cycle in cells, with specific emphasis on essential host factors. Insights into the cell biology of SARS-CoV-2 infection have accelerated the development of host-directed therapeutics, as shown by dozens of clinical trials evaluating COVID-19 treatments using host-targeting compounds.
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spelling pubmed-83790912021-08-23 Know your enemy and know yourself – the case of SARS-CoV-2 host factors Lee, Wai Suet Yousefi, Meisam Yan, Biaoguo Yong, Cythia Lingli Ooi, Yaw Shin Curr Opin Virol Article Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiologic agent that causes Coronavirus Disease 2019 (COVID-19) pandemic, is a newly emerging respiratory RNA virus with exceptional transmissibility and pathogenicity. Numerous COVID-19 related studies have been fast-tracked, with the ultimate goal to end the pandemic. Here we review the major stages of SARS-CoV-2 infection cycle in cells, with specific emphasis on essential host factors. Insights into the cell biology of SARS-CoV-2 infection have accelerated the development of host-directed therapeutics, as shown by dozens of clinical trials evaluating COVID-19 treatments using host-targeting compounds. Elsevier B.V. 2021-10 2021-08-21 /pmc/articles/PMC8379091/ /pubmed/34488003 http://dx.doi.org/10.1016/j.coviro.2021.08.007 Text en © 2021 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Lee, Wai Suet
Yousefi, Meisam
Yan, Biaoguo
Yong, Cythia Lingli
Ooi, Yaw Shin
Know your enemy and know yourself – the case of SARS-CoV-2 host factors
title Know your enemy and know yourself – the case of SARS-CoV-2 host factors
title_full Know your enemy and know yourself – the case of SARS-CoV-2 host factors
title_fullStr Know your enemy and know yourself – the case of SARS-CoV-2 host factors
title_full_unstemmed Know your enemy and know yourself – the case of SARS-CoV-2 host factors
title_short Know your enemy and know yourself – the case of SARS-CoV-2 host factors
title_sort know your enemy and know yourself – the case of sars-cov-2 host factors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379091/
https://www.ncbi.nlm.nih.gov/pubmed/34488003
http://dx.doi.org/10.1016/j.coviro.2021.08.007
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