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Doxycycline promotes proteasome fitness in the central nervous system

Several studies reported that mitochondrial stress induces cytosolic proteostasis in yeast and C. elegans. Notably, inhibition of mitochondrial translation with doxcycyline decreases the toxicity of β-amyloid aggregates, in a C. elegans. However, how mitochondrial stress activates cytosolic proteost...

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Detalles Bibliográficos
Autores principales:	Jenkins, Edmund Charles, O’Connell, Matthew J., Manfredi, Giovanni, Germain, Doris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379233/ https://www.ncbi.nlm.nih.gov/pubmed/34417525 http://dx.doi.org/10.1038/s41598-021-96540-z

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