Cargando…

Saturated very long chain fatty acid configures glycosphingolipid for lysosome homeostasis in long-lived C. elegans

The contents of numerous membrane lipids change upon ageing. However, it is unknown whether and how any of these changes are causally linked to lifespan regulation. Acyl chains contribute to the functional specificity of membrane lipids. In this study, working with C. elegans, we identified an acyl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Feng, Dai, Yuxi, Zhu, Xufeng, Chen, Qilong, Zhu, Huanhu, Zhou, Ben, Tang, Haiqing, Pang, Shanshan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379269/ https://www.ncbi.nlm.nih.gov/pubmed/34417467 http://dx.doi.org/10.1038/s41467-021-25398-6

Ejemplares similares

MFSD12 affects glycosphingolipid metabolism by modulating lysosome homeostasis
por: Hong, Yun, et al.
Publicado: (2022)

Glycosphingolipids with Very Long-Chain Fatty Acids Accumulate in Fibroblasts from Adrenoleukodystrophy Patients
por: Fujiwara, Yuko, et al.
Publicado: (2021)

Metabolism of Glycosphingolipids and Their Role in the Pathophysiology of Lysosomal Storage Disorders
por: Ryckman, Alex E., et al.
Publicado: (2020)

Very long-chain saturated fatty acids and diabetes and cardiovascular disease
por: Lemaitre, Rozenn N., et al.
Publicado: (2022)

Accumulation of Long-Chain Glycosphingolipids during Aging Is Prevented by Caloric Restriction
por: Hernández-Corbacho, María José, et al.
Publicado: (2011)

Saturated very long-chain fatty acids regulate macrophage plasticity and invasiveness
por: Zierfuss, Bettina, et al.
Publicado: (2022)

Genetic loci associated with circulating levels of very long-chain saturated fatty acids
por: Lemaitre, Rozenn N., et al.
Publicado: (2015)

SKN-1 Is a Negative Regulator of DAF-16 and Somatic Stress Resistance in Caenorhabditis elegans
por: Deng, Jianhui, et al.
Publicado: (2020)

Regulation of the lysosome by sphingolipids: Potential role in aging
por: Tang, Haiqing, et al.
Publicado: (2022)

Saturated Very Long Chain Fatty Acids Are Required for the Production of Infectious Human Cytomegalovirus Progeny
por: Koyuncu, Emre, et al.
Publicado: (2013)

Circulating Very Long‐Chain Saturated Fatty Acids and Heart Failure: The Cardiovascular Health Study
por: Lemaitre, Rozenn N., et al.
Publicado: (2018)

Serum Saturated Fatty Acids including Very Long-Chain Saturated Fatty Acids and Colorectal Cancer Risk among Chinese Population
por: Wu, Qixin, et al.
Publicado: (2023)

Too Long, Too Short, or Just Right: Glycosphingolipid–Protein Binding Varies with Acyl Chain Length
por: Robinson, Richard
Publicado: (2006)

Lipidomics of Glycosphingolipids
por: Farwanah, Hany, et al.
Publicado: (2012)

Intracellular Staphylococcus aureus Elicits the Production of Host Very Long-Chain Saturated Fatty Acids with Antimicrobial Activity
por: Bravo-Santano, Natalia, et al.
Publicado: (2019)

Dysregulation of very-long-chain fatty acid metabolism causes membrane saturation and induction of the unfolded protein response
por: Micoogullari, Yagmur, et al.
Publicado: (2020)

Disruption of Lysosome Function Promotes Tumor Growth and Metastasis in Drosophila
por: Chi, Congwu, et al.
Publicado: (2010)

Intestinal apical polarity mediates regulation of TORC1 by glucosylceramide in C. elegans
por: Zhu, Huanhu, et al.
Publicado: (2015)

Impaired selection of invariant natural killer T cells in diverse mouse models of glycosphingolipid lysosomal storage diseases
por: Gadola, Stephan D., et al.
Publicado: (2006)

The role of ELOVL1 in very long-chain fatty acid homeostasis and X-linked adrenoleukodystrophy
por: Ofman, Rob, et al.
Publicado: (2010)

Critical Role for Very-Long Chain Sphingolipids in Invariant Natural Killer T Cell Development and Homeostasis
por: Saroha, Ashish, et al.
Publicado: (2017)

Fenofibrate increases very-long-chain sphingolipids and improves blood glucose homeostasis in NOD mice
por: Holm, Laurits J., et al.
Publicado: (2019)

Glycosphingolipids in human parasites
por: Cummings, Richard D.
Publicado: (2023)

Regulation of lysosomal ion homeostasis by channels and transporters
por: Xiong, Jian, et al.
Publicado: (2016)

Low Circulating Concentrations of Very Long Chain Saturated Fatty Acids Are Associated with High Risk of Mortality in Kidney Transplant Recipients
por: Vogelpohl, Fabian A., et al.
Publicado: (2021)

Lifestyle Factors Associated with Circulating Very Long-Chain Saturated Fatty Acids in Humans: A Systematic Review of Observational Studies
por: Lai, Kira Zhi Hua, et al.
Publicado: (2022)

A Mouse Systems Genetics Approach Reveals Common and Uncommon Genetic Modifiers of Hepatic Lysosomal Enzyme Activities and Glycosphingolipids
por: Durán, Anyelo, et al.
Publicado: (2023)

Human Cytomegalovirus Uses a Host Stress Response To Balance the Elongation of Saturated/Monounsaturated and Polyunsaturated Very-Long-Chain Fatty Acids
por: Xi, Yuecheng, et al.
Publicado: (2021)

Characterization of moose intestinal glycosphingolipids
por: Johansson, Miralda Madar, et al.
Publicado: (2015)

Glycosphingolipids and neuroinflammation in Parkinson’s disease
por: Belarbi, Karim, et al.
Publicado: (2020)

Lyso-glycosphingolipids: presence and consequences
por: van Eijk, Marco, et al.
Publicado: (2020)

Glycosphingolipids Recognized by Acinetobacter baumannii
por: Madar Johansson, Miralda, et al.
Publicado: (2020)

Inhibition of Very Long Chain Fatty Acids Synthesis Mediates PI3P Homeostasis at Endosomal Compartments
por: Ito, Yoko, et al.
Publicado: (2021)

A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans
por: Zhu, Huanhu, et al.
Publicado: (2013)

Enhanced production of nitric oxide, reactive oxygen species, and pro-inflammatory cytokines in very long chain saturated fatty acid-accumulated macrophages
por: Yanagisawa, Naotake, et al.
Publicado: (2008)

Dietary Very Long Chain Saturated Fatty Acids and Metabolic Factors: Findings from the Korea National Health and Nutrition Examination Survey 2013
por: Lee, Youn Sue, et al.
Publicado: (2015)

Circulating Very-Long-Chain Saturated Fatty Acids Were Inversely Associated with Cardiovascular Health: A Prospective Cohort Study and Meta-Analysis
por: Liu, Meng, et al.
Publicado: (2020)

DNA damage promotes ER stress resistance through elevation of unsaturated phosphatidylcholine in Caenorhabditis elegans
por: Deng, Jianhui, et al.
Publicado: (2020)

Long-Chain and Very Long-Chain Ceramides Mediate Doxorubicin-Induced Toxicity and Fibrosis
por: Kretzschmar, Tom, et al.
Publicado: (2021)

Role of glycosphingolipid biosynthesis coregulators in malignant progression of thymoma
por: Zhang, Xin, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ajkl477n2kmsooq7p03ulth9s7