Revealing biomarkers associated with PARP inhibitors based on genetic interactions in cancer genome

Poly (ADPribose) polymerase inhibitors (PARPis) are clinically approved drugs designed according to the concept of synthetic lethality (SL) interaction. It is crucial to expand the scale of patients who can benefit from PARPis, and overcome drug resistance associated with it. Genetic interactions (G...

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Detalles Bibliográficos
Autores principales: Dong, Qi, Liu, Mingyue, Chen, Bo, Zhao, Zhangxiang, Chen, Tingting, Wang, Chengyu, Zhuang, Shuping, Li, Yawei, Wang, Yuquan, Ai, Liqiang, Liu, Yaoyao, Liang, Haihai, Qi, Lishuang, Gu, Yunyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379270/
https://www.ncbi.nlm.nih.gov/pubmed/34471490
http://dx.doi.org/10.1016/j.csbj.2021.08.007

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