Cargando…

A systems biology model of junctional localization and downstream signaling of the Ang–Tie signaling pathway

The Ang–Tie signaling pathway is an important vascular signaling pathway regulating vascular growth and stability. Dysregulation in the pathway is associated with vascular dysfunction and numerous diseases that involve abnormal vascular permeability and endothelial cell inflammation. The understandi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yu, Kontos, Christopher D., Annex, Brian H., Popel, Aleksander S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379279/ https://www.ncbi.nlm.nih.gov/pubmed/34417472 http://dx.doi.org/10.1038/s41540-021-00194-6

Ejemplares similares

Angiopoietin-Tie Signaling Pathway in Endothelial Cells: A Computational Model
por: Zhang, Yu, et al.
Publicado: (2019)

Experiment-based computational model predicts that IL-6 classic and trans-signaling exhibit similar potency in inducing downstream signaling in endothelial cells
por: Song, Min, et al.
Publicado: (2023)

A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use
por: Wu, Florence T H, et al.
Publicado: (2010)

Endothelial cells signaling and patterning under hypoxia: a mechanistic integrative computational model including the Notch-Dll4 pathway
por: Oliveira, Rebeca Hannah M, et al.
Publicado: (2023)

Characterization of the Ang/Tie2 Signaling Pathway in the Diaphragm Muscle of DMD Mice
por: Lin, Yiming, et al.
Publicado: (2023)

Experiment-based Computational Model Predicts that IL-6 Trans-Signaling Plays a Dominant Role in IL-6 mediated signaling in Endothelial Cells
por: Song, Min, et al.
Publicado: (2023)

Gamma-Tocotrienol Induces Apoptosis in Prostate Cancer Cells by Targeting the Ang-1/Tie-2 Signalling Pathway
por: Tang, Kai Dun, et al.
Publicado: (2019)

Endothelial Activation: The Ang/Tie Axis in Sepsis
por: Leligdowicz, Aleksandra, et al.
Publicado: (2018)

Sulfated glycans engage the Ang/Tie pathway to regulate vascular development
por: Griffin, Matthew E., et al.
Publicado: (2020)

The promoting effect of modified Dioscorea pills on vascular remodeling in chronic cerebral hypoperfusion via the Ang/Tie signaling pathway
por: Kuang, Guiying, et al.
Publicado: (2023)

Local and Systemic Overexpression of COMP-Ang1 Induces Ang1/Tie2-Related Thrombocytopenia and SDF-1/CXCR4-Dependent Anemia
por: Sim, Hyun-Jaung, et al.
Publicado: (2022)

Ang–Tie Angiogenic Pathway Is Distinctively Expressed in Benign and Malignant Adrenocortical Tumors
por: Oliveira, Sofia, et al.
Publicado: (2022)

Systems biology of angiogenesis signaling: Computational models and omics
por: Zhang, Yu, et al.
Publicado: (2021)

Inhibition of VEGFR2 Activation and Its Downstream Signaling to ERK1/2 and Calcium by Thrombospondin-1 (TSP1): In silico Investigation
por: Bazzazi, Hojjat, et al.
Publicado: (2017)

ANG-1 TIE-2 and BMPR Signalling Defects Are Not Seen in the Nitrofen Model of Pulmonary Hypertension and Congenital Diaphragmatic Hernia
por: Corbett, Harriet Jane, et al.
Publicado: (2012)

Suppression of Ocular Vascular Inflammation through Peptide-Mediated Activation of Angiopoietin-Tie2 Signaling
por: Mirando, Adam C., et al.
Publicado: (2020)

Inhibition of Protein Tyrosine Phosphatase Improves Angiogenesis via Enhancing Ang-1/Tie-2 Signaling in Diabetes
por: Chen, Jian-Xiong, et al.
Publicado: (2012)

Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression
por: Korhonen, Emilia A., et al.
Publicado: (2022)

Corrigendum: Inhibition of VEGFR2 Activation and Its Downstream Signaling to ERK1/2 and Calcium by Thrombospondin-1 (TSP1): In silico Investigation
por: Bazzazi, Hojjat, et al.
Publicado: (2017)

Computational drug repositioning for peripheral arterial disease: prediction of anti-inflammatory and pro-angiogenic therapeutics
por: Chu, Liang-Hui, et al.
Publicado: (2015)

Pericytes Contribute to Dysfunction in a Human 3D Model of Placental Microvasculature through VEGF‐Ang‐Tie2 Signaling
por: Haase, Kristina, et al.
Publicado: (2019)

Association of Ang/Tie2 pathway mediators with endothelial barrier integrity and disease severity in COVID-19
por: Moraes, Carla Roberta Peachazepi, et al.
Publicado: (2023)

Dynamic Multiscale Regulation of Perfusion Recovery in Experimental Peripheral Arterial Disease: A Mechanistic Computational Model
por: Zhao, Chen, et al.
Publicado: (2022)

BowTieBuilder: modeling signal transduction pathways
por: Supper, Jochen, et al.
Publicado: (2009)

A data-driven computational model enables integrative and mechanistic characterization of dynamic macrophage polarization
por: Zhao, Chen, et al.
Publicado: (2021)

Soluble Tei2 fusion protein inhibits retinopathy of prematurity occurrence via regulation of the Ang/Tie2 pathway
por: Li, Weijing, et al.
Publicado: (2019)

Engeletin protects against cerebral ischemia/reperfusion injury by modulating the VEGF/vasohibin and Ang-1/Tie-2 pathways
por: Liu, Hui, et al.
Publicado: (2021)

Granulocyte/Macrophage Colony-Stimulating Factor Influences Angiogenesis by Regulating the Coordinated Expression of VEGF and the Ang/Tie System
por: Zhao, Jingling, et al.
Publicado: (2014)

A study of the effects of hydroxyapatite bioceramic extract on Ang/Tie2 system of umbilical vein endothelial cells
por: Zhang, Xueyang, et al.
Publicado: (2021)

Hesperidin, a plant flavonoid accelerated the cutaneous wound healing in streptozotocin-induced diabetic rats: Role of TGF-ß/Smads and Ang-1/Tie-2 signaling pathways
por: Li, Wenbin, et al.
Publicado: (2018)

Angiopoietin–Tie signalling in the cardiovascular and lymphatic systems
por: Eklund, Lauri, et al.
Publicado: (2016)

Computer Simulation of TSP1 Inhibition of VEGF–Akt–eNOS: An Angiogenesis Triple Threat
por: Bazzazi, Hojjat, et al.
Publicado: (2018)

Computational investigation of sphingosine kinase 1 (SphK1) and calcium dependent ERK1/2 activation downstream of VEGFR2 in endothelial cells
por: Bazzazi, Hojjat, et al.
Publicado: (2017)

A mechanistic integrative computational model of macrophage polarization: Implications in human pathophysiology
por: Zhao, Chen, et al.
Publicado: (2019)

DPSCs treated by TGF-β1 regulate angiogenic sprouting of three-dimensionally co-cultured HUVECs and DPSCs through VEGF-Ang-Tie2 signaling
por: Zhang, Yuchen, et al.
Publicado: (2021)

Glutamate, Glutamate Receptors, and Downstream Signaling Pathways
por: Willard, Stacey S., et al.
Publicado: (2013)

Ang2 inhibitors and Tie2 activators: potential therapeutics in perioperative treatment of early stage cancer
por: Khan, Kabir A, et al.
Publicado: (2021)

Protocol for simulating macrophage signal transduction and phenotype polarization using a large-scale mechanistic computational model
por: Zhao, Chen, et al.
Publicado: (2021)

Mechanistic Computational Models of MicroRNA-Mediated Signaling Networks in Human Diseases
por: Zhao, Chen, et al.
Publicado: (2019)

Coexpression of Ang1 and Tie2 in Odontoblasts of Mouse Developing and Mature Teeth—A New Insight into Dentinogenesis
por: Nakajima, Kazunori, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_aer1hr3stj708u3e1t47j90gl3