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Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter
Despite the ability to characterize the plasticity of powders in a material-sparing and expedited manner, the in-die Heckel analysis has been widely criticized for its sensitivity to several factors, such as particle elastic deformation, tooling size, lubrication, and speed. Using materials exhibiti...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379284/ https://www.ncbi.nlm.nih.gov/pubmed/34458719 http://dx.doi.org/10.1016/j.ijpx.2021.100094 |
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author | Vreeman, Gerrit Sun, Changquan Calvin |
author_facet | Vreeman, Gerrit Sun, Changquan Calvin |
author_sort | Vreeman, Gerrit |
collection | PubMed |
description | Despite the ability to characterize the plasticity of powders in a material-sparing and expedited manner, the in-die Heckel analysis has been widely criticized for its sensitivity to several factors, such as particle elastic deformation, tooling size, lubrication, and speed. Using materials exhibiting a wide range of mechanical properties, we show that the in-die P(y) correlates strongly with three established plasticity parameters obtained from the out-of-die Heckel analysis, Kuentz-Leuenberger analysis, and macroindentation. Thus, the in-die P(y) is a reliable parameter for quantifying powder plasticity in a material-sparing and expedited manner. |
format | Online Article Text |
id | pubmed-8379284 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-83792842021-08-26 Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter Vreeman, Gerrit Sun, Changquan Calvin Int J Pharm X Research Paper Despite the ability to characterize the plasticity of powders in a material-sparing and expedited manner, the in-die Heckel analysis has been widely criticized for its sensitivity to several factors, such as particle elastic deformation, tooling size, lubrication, and speed. Using materials exhibiting a wide range of mechanical properties, we show that the in-die P(y) correlates strongly with three established plasticity parameters obtained from the out-of-die Heckel analysis, Kuentz-Leuenberger analysis, and macroindentation. Thus, the in-die P(y) is a reliable parameter for quantifying powder plasticity in a material-sparing and expedited manner. Elsevier 2021-08-14 /pmc/articles/PMC8379284/ /pubmed/34458719 http://dx.doi.org/10.1016/j.ijpx.2021.100094 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Paper Vreeman, Gerrit Sun, Changquan Calvin Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter |
title | Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter |
title_full | Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter |
title_fullStr | Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter |
title_full_unstemmed | Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter |
title_short | Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter |
title_sort | mean yield pressure from the in-die heckel analysis is a reliable plasticity parameter |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379284/ https://www.ncbi.nlm.nih.gov/pubmed/34458719 http://dx.doi.org/10.1016/j.ijpx.2021.100094 |
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