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Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter

Despite the ability to characterize the plasticity of powders in a material-sparing and expedited manner, the in-die Heckel analysis has been widely criticized for its sensitivity to several factors, such as particle elastic deformation, tooling size, lubrication, and speed. Using materials exhibiti...

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Detalles Bibliográficos
Autores principales: Vreeman, Gerrit, Sun, Changquan Calvin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379284/
https://www.ncbi.nlm.nih.gov/pubmed/34458719
http://dx.doi.org/10.1016/j.ijpx.2021.100094
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author Vreeman, Gerrit
Sun, Changquan Calvin
author_facet Vreeman, Gerrit
Sun, Changquan Calvin
author_sort Vreeman, Gerrit
collection PubMed
description Despite the ability to characterize the plasticity of powders in a material-sparing and expedited manner, the in-die Heckel analysis has been widely criticized for its sensitivity to several factors, such as particle elastic deformation, tooling size, lubrication, and speed. Using materials exhibiting a wide range of mechanical properties, we show that the in-die P(y) correlates strongly with three established plasticity parameters obtained from the out-of-die Heckel analysis, Kuentz-Leuenberger analysis, and macroindentation. Thus, the in-die P(y) is a reliable parameter for quantifying powder plasticity in a material-sparing and expedited manner.
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spelling pubmed-83792842021-08-26 Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter Vreeman, Gerrit Sun, Changquan Calvin Int J Pharm X Research Paper Despite the ability to characterize the plasticity of powders in a material-sparing and expedited manner, the in-die Heckel analysis has been widely criticized for its sensitivity to several factors, such as particle elastic deformation, tooling size, lubrication, and speed. Using materials exhibiting a wide range of mechanical properties, we show that the in-die P(y) correlates strongly with three established plasticity parameters obtained from the out-of-die Heckel analysis, Kuentz-Leuenberger analysis, and macroindentation. Thus, the in-die P(y) is a reliable parameter for quantifying powder plasticity in a material-sparing and expedited manner. Elsevier 2021-08-14 /pmc/articles/PMC8379284/ /pubmed/34458719 http://dx.doi.org/10.1016/j.ijpx.2021.100094 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Paper
Vreeman, Gerrit
Sun, Changquan Calvin
Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter
title Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter
title_full Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter
title_fullStr Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter
title_full_unstemmed Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter
title_short Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter
title_sort mean yield pressure from the in-die heckel analysis is a reliable plasticity parameter
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379284/
https://www.ncbi.nlm.nih.gov/pubmed/34458719
http://dx.doi.org/10.1016/j.ijpx.2021.100094
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