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In vivo urinary compatibility of Mg-Sr-Ag alloy in swine model

A biodegradable metallic ureteral stent with suitable mechanical properties and antibacterial activity remains a challenge. Here we reveal the scientific significance of a biodegradable Mg-Sr-Ag alloy with a favorable combination of balanced mechanical properties, adjustable indwelling time in urina...

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Autores principales: Tie, Di, Hort, Norbert, Chen, Minfang, Guan, Renguo, Ulasevich, Sviatlana, Skorb, Ekaterina V., Zhao, Dapeng, Liu, Yili, Holt-Torres, Patricia, Liu, Huinan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379362/
https://www.ncbi.nlm.nih.gov/pubmed/34466731
http://dx.doi.org/10.1016/j.bioactmat.2021.05.046
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author Tie, Di
Hort, Norbert
Chen, Minfang
Guan, Renguo
Ulasevich, Sviatlana
Skorb, Ekaterina V.
Zhao, Dapeng
Liu, Yili
Holt-Torres, Patricia
Liu, Huinan
author_facet Tie, Di
Hort, Norbert
Chen, Minfang
Guan, Renguo
Ulasevich, Sviatlana
Skorb, Ekaterina V.
Zhao, Dapeng
Liu, Yili
Holt-Torres, Patricia
Liu, Huinan
author_sort Tie, Di
collection PubMed
description A biodegradable metallic ureteral stent with suitable mechanical properties and antibacterial activity remains a challenge. Here we reveal the scientific significance of a biodegradable Mg-Sr-Ag alloy with a favorable combination of balanced mechanical properties, adjustable indwelling time in urinary tract and evident antibacterial activity via in vivo experiments in a swine model. Attributed to the rheo-solidification process, equiaxial microstructure and significantly refined grains (average grain size: 27.1 μm) were achieved. Mg(17)Sr(2) and Mg(4)Ag were found as the primary precipitates in the matrix, due to which the alloy obtained ca. 111% increase in ultimate tensile strength in comparison to pure magnesium. Both the in vitro and in vivo results demonstrated the satisfactory biocompatibility of the alloy. Histological evaluation and bioindicators analysis suggested that there was no tissue damage, inflammation and lesions in the urinary system caused by the degradation process. The stent also improved the post-operative bladder functions viewed from the urodynamic results. Our findings highlight the potential of this alloy as antibacterial biodegradable urinary implant material.
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spelling pubmed-83793622021-08-30 In vivo urinary compatibility of Mg-Sr-Ag alloy in swine model Tie, Di Hort, Norbert Chen, Minfang Guan, Renguo Ulasevich, Sviatlana Skorb, Ekaterina V. Zhao, Dapeng Liu, Yili Holt-Torres, Patricia Liu, Huinan Bioact Mater Article A biodegradable metallic ureteral stent with suitable mechanical properties and antibacterial activity remains a challenge. Here we reveal the scientific significance of a biodegradable Mg-Sr-Ag alloy with a favorable combination of balanced mechanical properties, adjustable indwelling time in urinary tract and evident antibacterial activity via in vivo experiments in a swine model. Attributed to the rheo-solidification process, equiaxial microstructure and significantly refined grains (average grain size: 27.1 μm) were achieved. Mg(17)Sr(2) and Mg(4)Ag were found as the primary precipitates in the matrix, due to which the alloy obtained ca. 111% increase in ultimate tensile strength in comparison to pure magnesium. Both the in vitro and in vivo results demonstrated the satisfactory biocompatibility of the alloy. Histological evaluation and bioindicators analysis suggested that there was no tissue damage, inflammation and lesions in the urinary system caused by the degradation process. The stent also improved the post-operative bladder functions viewed from the urodynamic results. Our findings highlight the potential of this alloy as antibacterial biodegradable urinary implant material. KeAi Publishing 2021-06-04 /pmc/articles/PMC8379362/ /pubmed/34466731 http://dx.doi.org/10.1016/j.bioactmat.2021.05.046 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Tie, Di
Hort, Norbert
Chen, Minfang
Guan, Renguo
Ulasevich, Sviatlana
Skorb, Ekaterina V.
Zhao, Dapeng
Liu, Yili
Holt-Torres, Patricia
Liu, Huinan
In vivo urinary compatibility of Mg-Sr-Ag alloy in swine model
title In vivo urinary compatibility of Mg-Sr-Ag alloy in swine model
title_full In vivo urinary compatibility of Mg-Sr-Ag alloy in swine model
title_fullStr In vivo urinary compatibility of Mg-Sr-Ag alloy in swine model
title_full_unstemmed In vivo urinary compatibility of Mg-Sr-Ag alloy in swine model
title_short In vivo urinary compatibility of Mg-Sr-Ag alloy in swine model
title_sort in vivo urinary compatibility of mg-sr-ag alloy in swine model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379362/
https://www.ncbi.nlm.nih.gov/pubmed/34466731
http://dx.doi.org/10.1016/j.bioactmat.2021.05.046
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