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An enamel-inspired bioactive material with multiscale structure and antibacterial adhesion property
Conventional dental materials lack of the hierarchical architecture of enamel that exhibits excellent intrinsic-extrinsic mechanical properties. Moreover, restorative failures frequently occur due to physical and chemical mismatch between artificial materials and native dental hard tissue followed b...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
KeAi Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379364/ https://www.ncbi.nlm.nih.gov/pubmed/34466748 http://dx.doi.org/10.1016/j.bioactmat.2021.05.035 |
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author | Wong, Hai Ming Zhang, Yu Yuan Li, Quan Li |
author_facet | Wong, Hai Ming Zhang, Yu Yuan Li, Quan Li |
author_sort | Wong, Hai Ming |
collection | PubMed |
description | Conventional dental materials lack of the hierarchical architecture of enamel that exhibits excellent intrinsic-extrinsic mechanical properties. Moreover, restorative failures frequently occur due to physical and chemical mismatch between artificial materials and native dental hard tissue followed by recurrent caries which is caused by sugar-fermenting, acidogenic bacteria invasion of the defective cite. In order to resolve the limitations of the conventional dental materials, the aim of this study was to establish a non-cell-based biomimetic strategy to fabricate a novel bioactive material with enamel-like structure and antibacterial adhesion property. The evaporation-based, bottom-up and self-assembly method with layer-by-layer technique were used to form a large-area fluorapatite crystal layer containing antibacterial components. The multilayered structure was constructed by hydrothermal growth of the fluorapatite crystal layer and highly conformal adsorption to the crystal surface of a polyelectrolyte matrix film. Characterization and mechanical assessment demonstrated that the synthesized bioactive material resembled the native enamel in chemical components, mechanical properties and crystallographic structure. Antibacterial and cytocompatibility evaluation demonstrated that this material had the antibacterial adhesion property and biocompatibility. In combination with the molecular dynamics simulations to reveal the effects of variables on the crystallization mechanism, this study brings new prospects for the synthesis of enamel-inspired materials. |
format | Online Article Text |
id | pubmed-8379364 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | KeAi Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-83793642021-08-30 An enamel-inspired bioactive material with multiscale structure and antibacterial adhesion property Wong, Hai Ming Zhang, Yu Yuan Li, Quan Li Bioact Mater Article Conventional dental materials lack of the hierarchical architecture of enamel that exhibits excellent intrinsic-extrinsic mechanical properties. Moreover, restorative failures frequently occur due to physical and chemical mismatch between artificial materials and native dental hard tissue followed by recurrent caries which is caused by sugar-fermenting, acidogenic bacteria invasion of the defective cite. In order to resolve the limitations of the conventional dental materials, the aim of this study was to establish a non-cell-based biomimetic strategy to fabricate a novel bioactive material with enamel-like structure and antibacterial adhesion property. The evaporation-based, bottom-up and self-assembly method with layer-by-layer technique were used to form a large-area fluorapatite crystal layer containing antibacterial components. The multilayered structure was constructed by hydrothermal growth of the fluorapatite crystal layer and highly conformal adsorption to the crystal surface of a polyelectrolyte matrix film. Characterization and mechanical assessment demonstrated that the synthesized bioactive material resembled the native enamel in chemical components, mechanical properties and crystallographic structure. Antibacterial and cytocompatibility evaluation demonstrated that this material had the antibacterial adhesion property and biocompatibility. In combination with the molecular dynamics simulations to reveal the effects of variables on the crystallization mechanism, this study brings new prospects for the synthesis of enamel-inspired materials. KeAi Publishing 2021-06-02 /pmc/articles/PMC8379364/ /pubmed/34466748 http://dx.doi.org/10.1016/j.bioactmat.2021.05.035 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Wong, Hai Ming Zhang, Yu Yuan Li, Quan Li An enamel-inspired bioactive material with multiscale structure and antibacterial adhesion property |
title | An enamel-inspired bioactive material with multiscale structure and antibacterial adhesion property |
title_full | An enamel-inspired bioactive material with multiscale structure and antibacterial adhesion property |
title_fullStr | An enamel-inspired bioactive material with multiscale structure and antibacterial adhesion property |
title_full_unstemmed | An enamel-inspired bioactive material with multiscale structure and antibacterial adhesion property |
title_short | An enamel-inspired bioactive material with multiscale structure and antibacterial adhesion property |
title_sort | enamel-inspired bioactive material with multiscale structure and antibacterial adhesion property |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379364/ https://www.ncbi.nlm.nih.gov/pubmed/34466748 http://dx.doi.org/10.1016/j.bioactmat.2021.05.035 |
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