Inhibition of 6-formylindolo[3,2-b]carbazole metabolism sensitizes keratinocytes to UVA-induced apoptosis: Implications for vemurafenib-induced phototoxicity

Ultraviolet (UV) B irradiation of keratinocytes results in the formation of the tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) which is a high-affinity ligand for the aryl hydrocarbon receptor (AHR). The resulting activation of AHR signaling induces the expression of cytochrome P450 (...

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Detalles Bibliográficos
Autores principales: Rolfes, Katharina M., Sondermann, Natalie C., Vogeley, Christian, Dairou, Julien, Gilardino, Viola, Wirth, Ragnhild, Meller, Stephan, Homey, Bernhard, Krutmann, Jean, Lang, Dieter, Nakamura, Motoki, Haarmann-Stemmann, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379514/
https://www.ncbi.nlm.nih.gov/pubmed/34418602
http://dx.doi.org/10.1016/j.redox.2021.102110

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