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Risk factors for disease progression in Japanese patients with COVID-19 with no or mild symptoms on admission
BACKGROUND: Although the risk factors for coronavirus disease 2019 (COVID-19) mortality have been identified, there is limited information about the risk factors for disease progression after hospitalization among Japanese patients with COVID-19 exhibiting no or mild symptoms. METHODS: All 302 conse...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379599/ https://www.ncbi.nlm.nih.gov/pubmed/34419004 http://dx.doi.org/10.1186/s12879-021-06574-x |
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author | Ninomiya, Toshifumi Otsubo, Kohei Hoshino, Teppei Shimokawa, Mototsugu Nakazawa, Megumi Sato, Yoriko Mikumo, Hironori Kawakami, Satoru Mizusaki, Shun Mori, Yusuke Arimura, Hidenobu Tsuchiya-Kawano, Yuko Inoue, Koji Uchida, Yujiro Nakanishi, Yoichi |
author_facet | Ninomiya, Toshifumi Otsubo, Kohei Hoshino, Teppei Shimokawa, Mototsugu Nakazawa, Megumi Sato, Yoriko Mikumo, Hironori Kawakami, Satoru Mizusaki, Shun Mori, Yusuke Arimura, Hidenobu Tsuchiya-Kawano, Yuko Inoue, Koji Uchida, Yujiro Nakanishi, Yoichi |
author_sort | Ninomiya, Toshifumi |
collection | PubMed |
description | BACKGROUND: Although the risk factors for coronavirus disease 2019 (COVID-19) mortality have been identified, there is limited information about the risk factors for disease progression after hospitalization among Japanese patients with COVID-19 exhibiting no or mild symptoms. METHODS: All 302 consecutive patients who were admitted to our institutions and diagnosed with COVID-19 between March and December 2020 were retrospectively assessed. Ultimately, 210 adult patients exhibiting no or mild symptoms on admission were included in the analysis. They were categorized into the stable (no oxygen needed) and worsened (oxygen needed) groups, and their characteristics and laboratory data were compared. RESULTS: Among 210 patients, 49 progressed to a severe disease stage, whereas 161 did not. The mean patient age was 52.14 years, and 126 (60.0%) patients were male. The mean body mass index (BMI) was 23.0 kg/m(2), and 71 patients were overweight (BMI ≥ 25 kg/m(2)). Multivariate logistic analysis showed that old age, overweight, diabetes mellitus (DM), and high serum ferritin levels were independent risk factors for disease progression. CONCLUSIONS: Clinicians should closely observe patients with COVID-19, especially those with risk factors such as old age, overweight, DM, and high serum ferritin levels, regardless of whether they have no or mild symptoms. |
format | Online Article Text |
id | pubmed-8379599 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-83795992021-08-23 Risk factors for disease progression in Japanese patients with COVID-19 with no or mild symptoms on admission Ninomiya, Toshifumi Otsubo, Kohei Hoshino, Teppei Shimokawa, Mototsugu Nakazawa, Megumi Sato, Yoriko Mikumo, Hironori Kawakami, Satoru Mizusaki, Shun Mori, Yusuke Arimura, Hidenobu Tsuchiya-Kawano, Yuko Inoue, Koji Uchida, Yujiro Nakanishi, Yoichi BMC Infect Dis Research BACKGROUND: Although the risk factors for coronavirus disease 2019 (COVID-19) mortality have been identified, there is limited information about the risk factors for disease progression after hospitalization among Japanese patients with COVID-19 exhibiting no or mild symptoms. METHODS: All 302 consecutive patients who were admitted to our institutions and diagnosed with COVID-19 between March and December 2020 were retrospectively assessed. Ultimately, 210 adult patients exhibiting no or mild symptoms on admission were included in the analysis. They were categorized into the stable (no oxygen needed) and worsened (oxygen needed) groups, and their characteristics and laboratory data were compared. RESULTS: Among 210 patients, 49 progressed to a severe disease stage, whereas 161 did not. The mean patient age was 52.14 years, and 126 (60.0%) patients were male. The mean body mass index (BMI) was 23.0 kg/m(2), and 71 patients were overweight (BMI ≥ 25 kg/m(2)). Multivariate logistic analysis showed that old age, overweight, diabetes mellitus (DM), and high serum ferritin levels were independent risk factors for disease progression. CONCLUSIONS: Clinicians should closely observe patients with COVID-19, especially those with risk factors such as old age, overweight, DM, and high serum ferritin levels, regardless of whether they have no or mild symptoms. BioMed Central 2021-08-21 /pmc/articles/PMC8379599/ /pubmed/34419004 http://dx.doi.org/10.1186/s12879-021-06574-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Ninomiya, Toshifumi Otsubo, Kohei Hoshino, Teppei Shimokawa, Mototsugu Nakazawa, Megumi Sato, Yoriko Mikumo, Hironori Kawakami, Satoru Mizusaki, Shun Mori, Yusuke Arimura, Hidenobu Tsuchiya-Kawano, Yuko Inoue, Koji Uchida, Yujiro Nakanishi, Yoichi Risk factors for disease progression in Japanese patients with COVID-19 with no or mild symptoms on admission |
title | Risk factors for disease progression in Japanese patients with COVID-19 with no or mild symptoms on admission |
title_full | Risk factors for disease progression in Japanese patients with COVID-19 with no or mild symptoms on admission |
title_fullStr | Risk factors for disease progression in Japanese patients with COVID-19 with no or mild symptoms on admission |
title_full_unstemmed | Risk factors for disease progression in Japanese patients with COVID-19 with no or mild symptoms on admission |
title_short | Risk factors for disease progression in Japanese patients with COVID-19 with no or mild symptoms on admission |
title_sort | risk factors for disease progression in japanese patients with covid-19 with no or mild symptoms on admission |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379599/ https://www.ncbi.nlm.nih.gov/pubmed/34419004 http://dx.doi.org/10.1186/s12879-021-06574-x |
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