Phosphorylated WNK kinase networks in recoded bacteria recapitulate physiological function

Advances in genetic code expansion have enabled the production of proteins containing site-specific, authentic post-translational modifications. Here, we use a recoded bacterial strain with an expanded genetic code to encode phosphoserine into a human kinase protein. We directly encode phosphoserine...

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Detalles Bibliográficos
Autores principales: Schiapparelli, Paula, Pirman, Natasha L., Mohler, Kyle, Miranda-Herrera, Pierre A., Zarco, Natanael, Kilic, Onur, Miller, Chad, Shah, Sagar R., Rogulina, Svetlana, Hungerford, William, Abriola, Laura, Hoyer, Denton, Turk, Benjamin E., Guerrero-Cázares, Hugo, Isaacs, Farren J., Quiñones-Hinojosa, Alfredo, Levchenko, Andre, Rinehart, Jesse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379681/
https://www.ncbi.nlm.nih.gov/pubmed/34289367
http://dx.doi.org/10.1016/j.celrep.2021.109416

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