Cargando…

A Randomized, Crossover, Adhesion Performance and Pharmacokinetic Study of a Lidocaine Topical System Under Conditions of Water Exposure in Healthy Subjects

PURPOSE: This study compares the adhesion performance, pharmacokinetic profile, and safety of lidocaine topical system 1.8%, which is approved to treat postherpetic neuralgia, under conditions of swimming and showering versus normal conditions. PATIENTS AND METHODS: This open-label, 3-period, 3-trea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vought, Kip, Greuber, Emileigh, Patel, Kalpana, Argoff, Charles, Lissin, Dmitri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379683/ https://www.ncbi.nlm.nih.gov/pubmed/34429646 http://dx.doi.org/10.2147/JPR.S323789

Ejemplares similares

A Randomized, Crossover, Pharmacokinetic and Adhesion Performance Study of a Lidocaine Topical System 1.8% During Physical Activity and Heat Treatment in Healthy Subjects
por: Fudin, Jeffrey, et al.
Publicado: (2020)

A Randomized, Open-Label, Bioequivalence Study of Lidocaine Topical System 1.8% and Lidocaine Patch 5% in Healthy Subjects
por: Gudin, Jeffrey, et al.
Publicado: (2020)

Open-Label Adhesion Performance Studies of a New Lidocaine Topical System 1.8% versus Lidocaine Patches 5% and Lidocaine Medicated Plaster 5% in Healthy Subjects
por: Gudin, Jeffrey, et al.
Publicado: (2021)

Open-Label Adhesion Performance Study of a Prescription Lidocaine Topical System 1.8% versus Three Lidocaine-Containing Over-the-Counter Patches in Healthy Subjects
por: Fudin, Jeffrey, et al.
Publicado: (2022)

Biorelevant In Vitro Skin Permeation Testing and In Vivo Pharmacokinetic Characterization of Lidocaine from a Nonaqueous Drug-in-Matrix Topical System
por: Greuber, Emileigh, et al.
Publicado: (2021)

Safety of Epidural Steroid Injections for Lumbosacral Radicular Pain: Unmet Medical Need
por: Cohen, Steven P., et al.
Publicado: (2021)

Topical Delivery Systems Effectively Transport Analgesics to Areas of Localized Pain via Direct Diffusion
por: Birngruber, Thomas, et al.
Publicado: (2023)

Pharmacokinetics of Lidocaine and Its Metabolites Following Vaginal Administration of Lidocaine Gel to Healthy Female Subjects
por: Martell, Bridget, et al.
Publicado: (2016)

Clinical effects and pharmacokinetics of nebulized lidocaine in healthy horses
por: Minuto, Jillian, et al.
Publicado: (2022)

Keratinocyte Biomarkers Distinguish Painful Diabetic Peripheral Neuropathy Patients and Correlate With Topical Lidocaine Responsiveness
por: Albrecht, Phillip J., et al.
Publicado: (2021)

Pharmacokinetics of oral pridinol: Results of a randomized, crossover bioequivalence trial in healthy subjects
por: Richter, Maren, et al.
Publicado: (2021)

Open-Label Crossover Study of Primaquine and Dihydroartemisinin-Piperaquine Pharmacokinetics in Healthy Adult Thai Subjects
por: Hanboonkunupakarn, Borimas, et al.
Publicado: (2014)

Pharmacokinetics and bioequivalence of sunitinib and Sutent(®) in Chinese healthy subjects: an open-label, randomized, crossover study
por: Wang, Yanli, et al.
Publicado: (2023)

Lidocaine-Loaded Hyaluronic Acid Adhesive Microneedle Patch for Oral Mucosal Topical Anesthesia
por: Zhu, Tingting, et al.
Publicado: (2022)

Dermal effects and pharmacokinetic evaluation of the lidocaine/prilocaine cream in healthy Chinese volunteers
por: Li, Lingjun, et al.
Publicado: (2023)

Topical Lidocaine for Chronic Pain Treatment
por: Voute, Marion, et al.
Publicado: (2021)

The Effect of Food Intake on the Pharmacokinetics of Oral Basal Insulin: A Randomised Crossover Trial in Healthy Male Subjects
por: Halberg, Inge B., et al.
Publicado: (2019)

Safety, tolerability, and pharmacokinetics of single and multiple topical ophthalmic administration of imatinib mesylate in healthy subjects
por: Na, Joo Young, et al.
Publicado: (2022)

A randomized crossover study of the effect of butorphanol–lidocaine and tramadol–lidocaine on sevoflurane's minimum alveolar concentration in dogs
por: Marzok, Mohamed, et al.
Publicado: (2023)

Repeat Epidural Injections of SP-102 (Dexamethasone Sodium Phosphate Injectable Gel) in Subjects with Lumbosacral Radiculopathy
por: Radnovich, Richard, et al.
Publicado: (2021)

Pharmacokinetics and Tolerability of Inhaled Umeclidinium and Vilanterol Alone and in Combination in Healthy Chinese Subjects: A Randomized, Open-Label, Crossover Trial
por: Hu, Chaoying, et al.
Publicado: (2015)

Pharmacokinetics and Bioequivalence of Sitagliptin Phosphate/Metformin Hydrochloride Tablets in Healthy Chinese Subjects: A Randomized, Open-Label, Crossover Study
por: Shi, Ping, et al.
Publicado: (2021)

Pharmacokinetics and bioequivalence of Ezetimibe tablet versus Ezetrol®:an open-label, randomized, two-sequence crossover study in healthy Chinese subjects
por: Sun, Feifei, et al.
Publicado: (2023)

Pharmacokinetics of Cabotegravir in Subjects with Severe Renal Impairment
por: Parasrampuria, Ridhi, et al.
Publicado: (2017)

Topical local anesthesia: focus on lidocaine–tetracaine combination
por: Giordano, Davide, et al.
Publicado: (2015)

Evaluation of Lidocaine and Metabolite Pharmacokinetics in Hyaluronic Acid Injection
por: Kim, Ju Hee, et al.
Publicado: (2021)

Pharmacokinetics of Cabotegravir in Subjects with Moderate Hepatic Impairment
por: Shaik, Jafar Sadik, et al.
Publicado: (2017)

Orally Formulated Artemisinin in Healthy Fasting Vietnamese Male Subjects: A Randomized, Four-Sequence, Open-Label, Pharmacokinetic Crossover Study
por: Hien, Tran Tinh, et al.
Publicado: (2011)

The effect of dipyridamole on the pharmacokinetics of metformin: a randomized crossover study in healthy volunteers
por: El Messaoudi, S., et al.
Publicado: (2016)

Propofol pharmacokinetics in young healthy Indian subjects
por: Puri, Avinash, et al.
Publicado: (2012)

Effects of Ketoconazole on the Pharmacokinetics of Ponatinib in Healthy Subjects
por: Narasimhan, Narayana I, et al.
Publicado: (2013)

Effects of food on the pharmacokinetics of ponatinib in healthy subjects
por: Narasimhan, NI, et al.
Publicado: (2013)

The effect of dolutegravir on the pharmacokinetics of metformin in healthy subjects
por: Zong, Jian, et al.
Publicado: (2014)

Pharmacokinetics and Safety of Defibrotide in Healthy Japanese Subjects
por: Umemura, Kazuo, et al.
Publicado: (2016)

Pharmacokinetic Properties of Rivaroxaban in Healthy Human Subjects
por: Bratsos, Sosipatros
Publicado: (2019)

Effect of Cilostazol on the Pharmacokinetics of Simvastatin in Healthy Subjects
por: Kim, Jung-Ryul, et al.
Publicado: (2019)

Ataluren Pharmacokinetics in Healthy Japanese and Caucasian Subjects
por: Kong, Ronald, et al.
Publicado: (2019)

The Effect of Dolutegravir on the Pharmacokinetics of Metformin in Healthy Subjects
por: Song, Ivy H., et al.
Publicado: (2016)

The effect of rifampin on the pharmacokinetics of famitinib in healthy subjects
por: Li, Ting, et al.
Publicado: (2022)

Pharmacokinetics of Imeglimin in Caucasian and Japanese Healthy Subjects
por: Fouqueray, Pascale, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_bltb7vc4e3jkcted30tbih04gb