Cargando…

Novel Timosaponin AIII-Based Multifunctional Liposomal Delivery System for Synergistic Therapy Against Hepatocellular Carcinoma Cancer

INTRODUCTION: As high cholesterol level has been reported to be associated with cancer cell growth and cholesterol is vulnerable to oxidation, the conventional liposomes including cholesterol in the formulation seem to be challenged. Timosaponin AIII (TAIII), as a steroid saponin from Anemarrhena as...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Lijuan, Zhang, Shengan, Jiang, Min, Lu, Lu, Ding, Yue, Ma, Ninghui, Zhao, Yuan, Xuchen, Sihan, Zhang, Nailian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379713/ https://www.ncbi.nlm.nih.gov/pubmed/34429598 http://dx.doi.org/10.2147/IJN.S313759

Ejemplares similares

Antibody-modified liposomes for tumor-targeting delivery of timosaponin AIII
por: Lu, Lu, et al.
Publicado: (2018)

The Potential Role of Timosaponin-AIII in Cancer Prevention and Treatment
por: Liu, Zhaowen, et al.
Publicado: (2023)

Synergistic anticancer effects of timosaponin AIII and ginsenosides in MG63 human osteosarcoma cells
por: Jung, Okkeun, et al.
Publicado: (2019)

Antiangiogenesis effect of timosaponin AIII on HUVECs in vitro and zebrafish embryos in vivo
por: Zhou, Zhong-yan, et al.
Publicado: (2019)

Rapid and Sensitive Determination of Timosaponin AIII in Rat Plasma by LC-MS/MS and Its Pharmacokinetic Application
por: Liu, Yanping, et al.
Publicado: (2013)

Comparison of the pharmacokinetics of timosaponin AIII, timosaponin BIII, and mangiferin extracted from crude and salt-processed Anemarrhenae Rhizoma by UPLC-MS/MS
por: Wang, XiaoTing, et al.
Publicado: (2023)

Blockage of Autophagy Increases Timosaponin AIII-Induced Apoptosis of Glioma Cells In Vitro and In Vivo
por: Lee, Chu-Che, et al.
Publicado: (2022)

Timosaponin AIII Suppresses RAP1 Signaling Pathway to Enhance the Inhibitory Effect of Paclitaxel on Nasopharyngeal Carcinoma
por: Li, Xiaofeng, et al.
Publicado: (2022)

Timosaponin AIII Is Preferentially Cytotoxic to Tumor Cells through Inhibition of mTOR and Induction of ER Stress
por: King, Frank W., et al.
Publicado: (2009)

Timosaponin AIII inhibits melanoma cell migration by suppressing COX‐2 and in vivo tumor metastasis
por: Kim, Ki Mo, et al.
Publicado: (2016)

Potential Antimetastatic Effect of Timosaponin AIII against Human Osteosarcoma Cells through Regulating the Integrin/FAK/Cofilin Axis
por: Hsieh, Yi-Hsien, et al.
Publicado: (2021)

Timosaponin AIII induces antiplatelet and antithrombotic activity via Gq-mediated signaling by the thromboxane A2 receptor
por: Cong, Yue, et al.
Publicado: (2016)

Pharmacological Activity, Pharmacokinetics, and Toxicity of Timosaponin AIII, a Natural Product Isolated From Anemarrhena asphodeloides Bunge: A Review
por: Lin, Yan, et al.
Publicado: (2020)

Ginsenoside Rg1 Drives Stimulations of Timosaponin AIII-Induced Anticancer Effects in Human Osteosarcoma Cells
por: Lee, Sang Yeol
Publicado: (2020)

Anemarrhena asphodeloides Bunge and its constituent timosaponin‐AIII induce cell cycle arrest and apoptosis in pancreatic cancer cells
por: MarElia, Catherine B., et al.
Publicado: (2018)

Functional Axis of PDE5/cGMP Mediates Timosaponin-AIII-Elicited Growth Suppression of Glioblastoma U87MG Cells
por: Liao, Ya-Fang, et al.
Publicado: (2023)

Retracted: Timosaponin AIII Suppresses RAP1 Signaling Pathway to Enhance the Inhibitory Effect of Paclitaxel on Nasopharyngeal Carcinoma
por: Methods in Medicine, Computational and Mathematical
Publicado: (2023)

Timosaponin AIII promotes non-small-cell lung cancer ferroptosis through targeting and facilitating HSP90 mediated GPX4 ubiquitination and degradation
por: Zhou, Cong, et al.
Publicado: (2023)

Timosaponin AIII Induces G2/M Arrest and Apoptosis in Breast Cancer by Activating the ATM/Chk2 and p38 MAPK Signaling Pathways
por: Zhang, Minjie, et al.
Publicado: (2021)

Timosaponin AIII Suppresses Hepatocyte Growth Factor-Induced Invasive Activity through Sustained ERK Activation in Breast Cancer MDA-MB-231 Cells
por: Tsai, Chung-Hsin, et al.
Publicado: (2013)

Timosaponin AIII Inhibits Migration and Invasion Abilities in Human Cervical Cancer Cells through Inactivation of p38 MAPK-Mediated uPA Expression In Vitro and In Vivo
por: Chien, Hung-Ju, et al.
Publicado: (2022)

Multifunctional targeted liposomal drug delivery for efficient glioblastoma treatment
por: Belhadj, Zakia, et al.
Publicado: (2017)

Multifunctional quantum dots and liposome complexes in drug delivery
por: Wang, Qi, et al.
Publicado: (2018)

TPGS Decorated Liposomes as Multifunctional Nano-Delivery Systems
por: Farooq, Muhammad Asim, et al.
Publicado: (2022)

Multifunctional icariin and tanshinone IIA co-delivery liposomes with potential application for Alzheimer’s disease
por: Wang, Jiao, et al.
Publicado: (2022)

Biotransformation of Timosaponin BII into Seven Characteristic Metabolites by the Gut Microbiota
por: Dong, Guo-Ming, et al.
Publicado: (2021)

Multifunctional Nanoplatform Based on Sunitinib for Synergistic Phototherapy and Molecular Targeted Therapy of Hepatocellular Carcinoma
por: Xu, Wenjing, et al.
Publicado: (2023)

Co-delivery of docetaxel and palmitoyl ascorbate by liposome for enhanced synergistic antitumor efficacy
por: Li, Junxiu, et al.
Publicado: (2016)

Lactosylated liposomes for targeted delivery of doxorubicin to hepatocellular carcinoma
por: Zhou, Xiaoju, et al.
Publicado: (2012)

MLN51 Stimulates the RNA-Helicase Activity of eIF4AIII
por: Noble, Christian G., et al.
Publicado: (2007)

The oncogenic neurotrophin receptor tropomyosin-related kinase variant, TrkAIII
por: Farina, Antonietta Rosella, et al.
Publicado: (2018)

Liposomes as Multifunctional Nano-Carriers for Medicinal Natural Products
por: Cheng, Xiamin, et al.
Publicado: (2022)

The effect and underlying mechanism of Timosaponin B-II on RGC-5 necroptosis induced by hydrogen peroxide
por: Jiang, San-Hong, et al.
Publicado: (2014)

Multifunctional Nanocomposite Films for Synergistic Delivery of bFGF and BMP-2
por: Qi, Wei, et al.
Publicado: (2017)

Timosaponin-BII inhibits the up-regulation of BACE1 induced by Ferric Chloride in rat retina
por: Huang, Ju-Fang, et al.
Publicado: (2012)

Novel ginsenoside-based multifunctional liposomal delivery system for combination therapy of gastric cancer
por: Hong, Chao, et al.
Publicado: (2019)

Synergistical Use of Electrostatic and Hydrophobic Interactions for the Synthesis of a New Class of Multifunctional Nanohybrids: Plasmonic Magneto-Liposomes
por: Știufiuc, Gabriela Fabiola, et al.
Publicado: (2019)

Identification of “sarsasapogenin-aglyconed” timosaponins as novel Aβ-lowering modulators of amyloid precursor protein processing
por: Sy, Lai-King, et al.
Publicado: (2016)

Molecular Pathways Involved in Promoting Activity of Timosaponin BII on Hair Growth in C57BL/6 Mice
por: Xiao, Lei, et al.
Publicado: (2020)

Overexpression of patatin-related phospholipase AIIIβ altered the content and composition of sphingolipids in Arabidopsis
por: Li, Maoyin, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_i1r8k3tp9v2bhqq1somvhsb422