Engineered basic fibroblast growth factor-overexpressing human umbilical cord-derived mesenchymal stem cells improve the proliferation and neuronal differentiation of endogenous neural stem cells and functional recovery of spinal cord injury by activating the PI3K-Akt-GSK-3β signaling pathway

OBJECTIVES: To investigate the safety for clinic use and therapeutic effects of basic fibroblast growth factor (bFGF)-overexpressing human umbilical cord-derived mesenchymal stem cells (HUCMSCs) in mice with completely transected spinal cord injury (SCI). METHODS: Stable bFGF-overexpressing HUCMSCs...

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Detalles Bibliográficos
Autores principales: Huang, Feifei, Gao, Tianyun, Wang, Wenqing, Wang, Liudi, Xie, Yuanyuan, Tai, Chenxun, Liu, Shuo, Cui, Yi, Wang, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379754/
https://www.ncbi.nlm.nih.gov/pubmed/34419172
http://dx.doi.org/10.1186/s13287-021-02537-w

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