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Assessment of turbulent blood flow and wall shear stress in aortic coarctation using image-based simulations

In this study, we analyzed turbulent flows through a phantom (a 180[Formula: see text] bend with narrowing) at peak systole and a patient-specific coarctation of the aorta (CoA), with a pulsating flow, using magnetic resonance imaging (MRI) and computational fluid dynamics (CFD). For MRI, a 4D-flow...

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Autores principales: Perinajová, Romana, Juffermans, Joe F., Mercado, Jonhatan Lorenzo, Aben, Jean-Paul, Ledoux, Leon, Westenberg, Jos J. M., Lamb, Hildo J., Kenjereš, Saša
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379896/
https://www.ncbi.nlm.nih.gov/pubmed/34419047
http://dx.doi.org/10.1186/s12938-021-00921-4
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author Perinajová, Romana
Juffermans, Joe F.
Mercado, Jonhatan Lorenzo
Aben, Jean-Paul
Ledoux, Leon
Westenberg, Jos J. M.
Lamb, Hildo J.
Kenjereš, Saša
author_facet Perinajová, Romana
Juffermans, Joe F.
Mercado, Jonhatan Lorenzo
Aben, Jean-Paul
Ledoux, Leon
Westenberg, Jos J. M.
Lamb, Hildo J.
Kenjereš, Saša
author_sort Perinajová, Romana
collection PubMed
description In this study, we analyzed turbulent flows through a phantom (a 180[Formula: see text] bend with narrowing) at peak systole and a patient-specific coarctation of the aorta (CoA), with a pulsating flow, using magnetic resonance imaging (MRI) and computational fluid dynamics (CFD). For MRI, a 4D-flow MRI is performed using a 3T scanner. For CFD, the standard [Formula: see text] , shear stress transport [Formula: see text] , and Reynolds stress (RSM) models are applied. A good agreement between measured and simulated velocity is obtained for the phantom, especially for CFD with RSM. The wall shear stress (WSS) shows significant differences between CFD and MRI in absolute values, due to the limited near-wall resolution of MRI. However, normalized WSS shows qualitatively very similar distributions of the local values between MRI and CFD. Finally, a direct comparison between in vivo 4D-flow MRI and CFD with the RSM turbulence model is performed in the CoA. MRI can properly identify regions with locally elevated or suppressed WSS. If the exact values of the WSS are necessary, CFD is the preferred method. For future applications, we recommend the use of the combined MRI/CFD method for analysis and evaluation of the local flow patterns and WSS in the aorta.
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spelling pubmed-83798962021-08-23 Assessment of turbulent blood flow and wall shear stress in aortic coarctation using image-based simulations Perinajová, Romana Juffermans, Joe F. Mercado, Jonhatan Lorenzo Aben, Jean-Paul Ledoux, Leon Westenberg, Jos J. M. Lamb, Hildo J. Kenjereš, Saša Biomed Eng Online Research In this study, we analyzed turbulent flows through a phantom (a 180[Formula: see text] bend with narrowing) at peak systole and a patient-specific coarctation of the aorta (CoA), with a pulsating flow, using magnetic resonance imaging (MRI) and computational fluid dynamics (CFD). For MRI, a 4D-flow MRI is performed using a 3T scanner. For CFD, the standard [Formula: see text] , shear stress transport [Formula: see text] , and Reynolds stress (RSM) models are applied. A good agreement between measured and simulated velocity is obtained for the phantom, especially for CFD with RSM. The wall shear stress (WSS) shows significant differences between CFD and MRI in absolute values, due to the limited near-wall resolution of MRI. However, normalized WSS shows qualitatively very similar distributions of the local values between MRI and CFD. Finally, a direct comparison between in vivo 4D-flow MRI and CFD with the RSM turbulence model is performed in the CoA. MRI can properly identify regions with locally elevated or suppressed WSS. If the exact values of the WSS are necessary, CFD is the preferred method. For future applications, we recommend the use of the combined MRI/CFD method for analysis and evaluation of the local flow patterns and WSS in the aorta. BioMed Central 2021-08-21 /pmc/articles/PMC8379896/ /pubmed/34419047 http://dx.doi.org/10.1186/s12938-021-00921-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Perinajová, Romana
Juffermans, Joe F.
Mercado, Jonhatan Lorenzo
Aben, Jean-Paul
Ledoux, Leon
Westenberg, Jos J. M.
Lamb, Hildo J.
Kenjereš, Saša
Assessment of turbulent blood flow and wall shear stress in aortic coarctation using image-based simulations
title Assessment of turbulent blood flow and wall shear stress in aortic coarctation using image-based simulations
title_full Assessment of turbulent blood flow and wall shear stress in aortic coarctation using image-based simulations
title_fullStr Assessment of turbulent blood flow and wall shear stress in aortic coarctation using image-based simulations
title_full_unstemmed Assessment of turbulent blood flow and wall shear stress in aortic coarctation using image-based simulations
title_short Assessment of turbulent blood flow and wall shear stress in aortic coarctation using image-based simulations
title_sort assessment of turbulent blood flow and wall shear stress in aortic coarctation using image-based simulations
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379896/
https://www.ncbi.nlm.nih.gov/pubmed/34419047
http://dx.doi.org/10.1186/s12938-021-00921-4
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