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Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol

Alzheimer’s disease (AD) is characterized by the presence of amyloid β (Aβ) plaques, tau tangles, inflammation, and loss of cognitive function. Genetic variation in a cholesterol transport protein, apolipoprotein E (apoE), is the most common genetic risk factor for sporadic AD. In vitro evidence sug...

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Detalles Bibliográficos
Autores principales:	Wang, Hao, Kulas, Joshua A., Wang, Chao, Holtzman, David M., Ferris, Heather A., Hansen, Scott B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2021
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379952/ https://www.ncbi.nlm.nih.gov/pubmed/34385305 http://dx.doi.org/10.1073/pnas.2102191118

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