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Structure of autoinhibited Akt1 reveals mechanism of PIP(3)-mediated activation

The protein kinase Akt is one of the primary effectors of growth factor signaling in the cell. Akt responds specifically to the lipid second messengers phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P(3)] and phosphatidylinositol-3,4-bisphosphate [PI(3,4)P(2)] via its PH domain, leading to phosp...

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Detalles Bibliográficos
Autores principales:	Truebestein, Linda, Hornegger, Harald, Anrather, Dorothea, Hartl, Markus, Fleming, Kaelin D., Stariha, Jordan T. B., Pardon, Els, Steyaert, Jan, Burke, John E., Leonard, Thomas A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2021
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379990/ https://www.ncbi.nlm.nih.gov/pubmed/34385319 http://dx.doi.org/10.1073/pnas.2101496118

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